7 enzyme action - Reaction coordinate Energy, G ∆ G react...

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Unformatted text preview: Reaction coordinate Energy, G ∆ G react ants products Reaction coordinate Energy, G ∆ G reactants products Energy diagrams Exergonic Endergon ic Reaction coordinate ∆ G ∆ G = activation energy Energy, G products reactants Energy diagram over the course of a reaction Derivation of G G = H – TS Change of free energy Δ G = Δ H- T Δ S units are kJ/mol For the reaction A + B C + D Δ G = Δ G° + RT ln [C][D] / [A][B] Where Δ G° is the standard free energy change defined as the free energy change at 25 ° C (298 ° K) and 1 atm pressure and [ ] of all reactants and products = 1 M I f Δ G is negative, the reactions is exothermic and spontaneous At equilibrium Δ G = 0 because forward and reverse reactions are equal Standard free energy – 25 ° , 1 atm, [ ] = 1 M I n biochemistry, reactions occur at neutral pH in aqueous solution Rather than include [H + ] = 10-7 M and [H 2 O] = 55 M, we define a new standard free energy change where [H + ] and [H 2 O] = 1 and we call it Δ G°’. G°’....
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This note was uploaded on 08/23/2011 for the course BIOCHEM 352 taught by Professor Nicholas during the Spring '11 term at Ill. Chicago.

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7 enzyme action - Reaction coordinate Energy, G ∆ G react...

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