7 enzyme action - Ener gy diagr ams pr oduct s G Exer gonic...

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Reaction coordinate Energy, G G reactants products Reaction coordinate Energy, G G reactants products Energy diagrams Exergonic Endergon ic
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Reaction coordinate G G = activation energy Energy, G products reactants Energy diagram over the course of a reaction
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Derivation of G G = H – TS Change of free energy Δ G = Δ H- T Δ S units are kJ/mol For the reaction A + B C + D Δ G = Δ + RT ln [C][D] / [A][B] Where Δ G° is the standard free energy change defined as the free energy change at 25 ° C (298 ° K) and 1 atm pressure and [ ] of all reactants and products = 1 M If Δ G is negative, the reactions is exothermic and spontaneous At equilibrium Δ G = 0 because forward and reverse reactions are equal Standard free energy – 25 ° , 1 atm, [ ] = 1 M
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In biochemistry, reactions occur at neutral pH in aqueous solution Rather than include [H + ] = 10 -7 M and [H 2 O] = 55 M, we define a new standard free energy change where [H + ] and [H 2 O] = 1 and we call it Δ G°’. The remainder of the relationships remain the same.
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