{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

153Cwinter09exam11 - ,unistry 153C winter 09.186 print and...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 2
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 4
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 6
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 8
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: ,unistry 153C, winter 09 .186 print and sign your full name below and provide your student ID. On the subsequent pages, please print your last name. The exam should be completed in 50 minutes. The only materials allowed on your desk are pencil/pen and eraser. Calculators are not needed and books and notes are not allowed. Printed Name Last, First Student ID # Signature Points: Page 2 / 16 Page 3 /24 ' Page 4 / 12 Page 5 /20 Page 6 /15 Page 7 /13 Total / 100 ‘ Page 2 of 8 Exam I Chem 153C, winter 09 Name 1. Answer the short answer questions below. (8 points) A. Lipoprotein lipase General Function Location in body B. Pancreatic Lipase Locat1on in body _ M 1ch WW PM W M a «c Liase General Funcuon FD!” /¢f{0¢( a F/a S f0 éZOoo/ ow W cm D _2hospholipid Lipase _e—neral Function ‘ 2. In the New York Times article discussed in class, the person ate the unripe fruit of the ackee tree and became sick. -—A-) What enzyme is inhibited when this fruit 15 eaten (2 points) flCA) (/1?me 04.1.14. QQ‘XKwA‘fl/ [weak] : B) What metabolites accumulate as a result of this inhibition? (2 points) M54" 16713 de-‘n v]— o {-193 x) 0‘15, (ROLA(§U3 ocfdkoc'fi duo/’7 m‘d'y/ a “$0 M) C) What IS the specific reason why the person had hypoglycemia (4 points)? PM [Aiulen W r >4 bawdy 1465 w mm Mood Ar FA; ”LU/‘0" 0k ago/+3 «Jaduu’ Jud/35 So" i/CSLVCOK '1’0 1&(04 WSSMOI C(ucav SW’O V1 jhjcvcyw chit/Cd” Do i— .‘A Timo’ jiuuv. Page 3 of 8 Exam I Chem 153C, winter 09 Name 3. There is a new odd chain fatty acid that is found in a plant. You really like to eat this plant because it tastes good. Answer the following questions about how B-oxidation proceeds. The formula is: C1722 cis A7 cis A10 9 a How many rounds of B-oxidation will this molecule undergo? ( 2 points) i b. What are the net number of “energy” molecules (NADH, ATP, FADI-I2, NADP+) generated per round of [3- oxidation ? (16 points) Round # of B- List of energy molecules generated per round oxidation c. What are the structure(s) of the C-containing compounds generated from B-oxidation and how many are there of each compound? (4 points) P 3r ACCoA CH5 44604 0 . May/290d GA 073 — (7/1 » CH— fG/q l 3. d. What is the rate limiting step for the B-oxidation of this lipid? (2 points) fie L umhl‘m Sic/7W Page 4 of 8 Exam I Chem 153C, winter 09 Name . 3 e. For the last product of the B-oxidation of the fatty acid C17:2 cis A7, cis A10 (the one that is in a lower ‘ amount), how does it enter a central metabolic pathway in a human? Show the pathway with structures and ' indicate the necessary co-factors. Enzyme names are not needed. (12 points) ( Hog ‘ ch QI-lz BMW? -60 (Acid; i Page 5 of 8 Exam I Chem 153C, winter 09 Name 3. f. For the last product of the B-oxidation of the fatty acid C17:2 cis A7, cis A10 (the one that is in a lower amount), it is incorporated into the glyoxylate cycle in place of the typical two-carbon containing compound. Show how the cycle would proceed starting at condensation with oxaloacetate. Draw the structures and indicate the key enzymes in the glyoxylate cycle. (20 points) Is it possible to regenerate oxaloacetate? _________ 10' 9’ 000- 9’ 9°“ " | 3 jcgo h? ,067‘3‘5.“ I (‘6’ . | I? 3 CH )_ l COO (53 ‘Cfi’z C—S‘QA (0?: 3 >8 / c “3 \ OIA kc ‘ COO/ (.7 a ’ / 0‘3 ’ I! “’0 ’- C ‘ COO ’ f (H , 0 *©' c —o’ 1" C/ ' ’ 1L} f’\ 7 C :0 Page 6 of 8 Exam I Chem 153C, winter 09 Name 4. Two key reactions in pentose phosphate pathway involved reactions with transketolase and transaldolase. Show the products from a reaction series starting with transketolase and finishing with transaldolase. Indicate where the carbonyl on the sugars is located (use shorthand as demonstrated) and indicate where the labels move when starting with the following two sugars (12 points): C IQ=O é : c) c c C) I ' El Q. CI=O lC K6 [‘5 {9&6 \\ H fl/JW *6: a: 1r? - c + I I C l (.3 (.3 I $— C-P C-P c - { Q l. C. 5. Sustained oxidation of fatty acids as a major carbon and energy source during growth requires a simultaneous anaplerotic reaction other than the normal operation of the cycle reactions themselves to replenish the pool of dicarboxylic acids of the tricarboxylic acid cycle. For following situation indicate the immediate enzyme-catalyzed reaction (using structures except for coenzymes, which may be abbreviated in standard fashion) which would be serving to replenish the pool of one of the dicarboxylic acids of the TCA cycle. If no replenishment reaction would be occurring indicate NONE. (c) Oxidation of fatty acids as a major carbon source in a mammalian cell also carrying out the catabolism of L-alanine. (3 points) ' Page 7 of 8 Exam I Chem 153C, winter 09 Name 6. Illustrate with formulas (structures are NOT necessary) one reaction of physiological importance for each of the following cases. Coenzymes may be abbreviated in standard fashion; intermediates and mechanisms need not be indicated. In each case state briefl y a function in metabolism for the reaction you have shown. a) A reaction catalyzed by pyrophosphatase. (3 points) 7' ’(DP 7 "L ( HIO b) A reaction in which camitine participates as a substrate. (3 points) 7. An individual developed a condition characterized by progressive muscular weakness and aching muscle cramps. The symptoms were worsened by fasting, exercise, and 'a hi gh-fat diet. The homogenate of a skeletal muscle specimen from the patient oxidized oleate more slowly than did control homogenates, consisting of muscle specimens from healthy people. When camitine was added to the patient’s muscle homogenate, the rate of oleate oxidation equaled that of the homogenates from the healthy individuals. The patient was diagnosed with camitine deficiency. ‘ ‘ a) Why did added camitine increase the rate of oleate oxidation. in the-patient’s muscle hpmpgenates? (2 points) "“ ‘ ‘ ' C‘J/n.“h‘nk {Ac #4, As; flax/2574M”. b) Why were the patient’s symptoms worsened by fasting, exercise, and a hi gh-fat diet? (2 points) beau,“ My suite/.5 MJ FA Oat/“A 5? “1/3 c) Suggest a possible reason fort e deficiency of muscle camitine in this individual. (3 points) [My MAI/’1 (“n C(fnc'fi‘u 5w é/‘dgf/I’fi‘fj ...
View Full Document

{[ snackBarMessage ]}