5-423-08ComplexLipids

5-423-08ComplexLipids - 1 Synthesis of TAGs(1 Synthesis of...

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Unformatted text preview: * 1 Synthesis of TAGs (1) Synthesis of TAGs (2) 2 Synthesis of TAGs (3) 3 Bile Acids: polar derivatives of cholesterol that act as detergents in the intestine, emulsifying dietary fats, making them more accessible to digestive lipases. 4 Steroids: Oxidized derivatives of sterols. They have the sterol nucleus but lack the akyl chain. 5 Synthesis of cholesterol (1) Synthesis of cholesterol (2, 3, 4) 6 Control of cholesterol synthesis Statins--X--> Competitive inhibitors of HMG-CoA reductase 7 Membranes Lipid transport in the circulation Lipids are insoluble in plasma. In order to be transported they are combined with specific proteins to form lipoproteins: Phospholipid Proteins (apoproteins) HO O Cholesterol HO R O R Non polar lipids in core (triacylglycerols and cholesterol esters) HO Apoproteins are only weakly associated with a particular lipoprotein and are easily transferred to another lipoprotein of a different class. Apoproteins have various functions including: Structural role Binding sites for receptors Activators or co-enzymes for enzymes involved with lipid metabolism 8 The Four Classes of Lipoprotein (all contain characteristic amounts triacylglycerol, cholesterol, cholesterol esters, phospholipids and apoproteins) Class Chylomicrons (CM) Increasing density Diameter (nm) 500 43 Source and function Intestine. Transport of dietary TAG Liver. Transport of endogenously synthesised TAG Formed in circulation by partial breakdown of IDL. Delivers cholesterol to peripheral tissues Liver. Removes "used" cholesterol from tissues and takes it to liver. Donates apolipoproteins to CM and VLDL Major apoliproteins A, B48, C(I,II,III) E B100, C(I,II,III) , E B100 Very low density lipoproteins (VLDL) Low density lipoproteins (LDL) High density lipoproteins (HDL) 22 8 A, C(I,II,III), D, E Lipoprotein Composition 9 4 classes of lipoproteins visualized by electron microscope 10 Chylomicron * 11 LDL 12 * 13 ...
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This note was uploaded on 04/05/2008 for the course BIOCHEM 423 taught by Professor Osgood during the Spring '08 term at New Mexico.

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5-423-08ComplexLipids - 1 Synthesis of TAGs(1 Synthesis of...

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