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5-423-08ComplexLipids - 1 Synthesis of TAGs(1 Synthesis of...

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2 Synthesis of TAGs (1) Synthesis of TAGs (2)
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3 Synthesis of TAGs (3)
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4 Bile Acids: polar derivatives of cholesterol that act as detergents in the intestine, emulsifying dietary fats, making them more accessible to digestive lipases.
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5 Steroids: Oxidized derivatives of sterols. They have the sterol nucleus but lack the akyl chain.
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6 Synthesis of cholesterol (1) Synthesis of cholesterol (2, 3, 4)
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7 Control of cholesterol synthesis Statins--X--> Competitive inhibitors of HMG-CoA reductase
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8 Membranes Lipid transport in the circulation Lipids are insoluble in plasma. In order to be transported they are combined with specific proteins to form lipoproteins: Non polar lipids in core (triacylglycerols and cholesterol esters ) Proteins (apoproteins) Cholesterol Apoproteins are only weakly associated with a particular lipoprotein and are easily transferred to another lipoprotein of a different class. Apoproteins have various functions including: Structural role Binding sites for receptors Activators or co-enzymes for enzymes involved with lipid metabolism
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