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4-423-08FASynthesis - Excess fats from diet can be...

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1 Excess fats from diet can be incorporated into TAGs in adipocytes Excess carbohydrates (and excess carbon skeletons from amino acid breakdown) can be stored as fat (NOTE: but excess fats can NOT be made into glucose or stored as glycogen…)
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2 Breakdown of glucose to acetyl-CoA through glycolysis, pyruvate dehydrogenase. Acetyl-CoA is the starting point for fatty acid synthesis. Comparison of Fatty acid Oxidation and Fatty acid Synthesis Oxidation Synthesis Matrix Cytosol If synthesis occurs in the cytosol, and the acetyl CoAs are in the matrix, how to get them out?
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3 How to get acetyl-CoA out of matrix into cytoplasm? The citrate transporter. 1. 2. 3. 4. 5. Comparison of Fatty acid Oxidation and Fatty acid Synthesis Oxidation Synthesis Matrix Cytosol Involves removal of Involves addition acetyl groups of malonyl groups Fatty acids are built up two carbons at a time, but the group added each time (after the first one) is a three-carbon piece, Malonyl CoA which is made from acetyl-CoA and CO 2 (HCO 3 -)
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