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17 Glycogen - Biochemistry Education BIOC 423 Introductory...

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Glycogen OBJECTIVES Be able to describe the physiological role of glycogen in regulating glucose homeostasis Be able to recognize, and draw the α 1 Æ 4 and α 1 Æ 6 glycosidic bonds present in glycogen. Know the reactions involved in glycogen synthesis from glucose 6- phosphate. Know the reactions involved in the breakdown of glycogen. Understand how glycogen metabolism is regulated by hormones. OUTLINE Metabolic/Physiological Role of Glycogen Fed state Starvation Glycogen/Starch Structure Breakdown (Glycogenolysis) – Liberating Glucose Phosphorylase Debranching enzyme complex Glucose Activation Generic model for biopolymer synthesis (Trap - Activate - Transfer) UDP activation Glycogen Synthesis Glycogen synthetase Branching enzyme ( α 1 Æ 4:: α 1 Æ 6 transferase) Insulin / Glucagon regulation
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