10-Cell_cycle_and_migration - Cell Cycle and Migration Cell...

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Cell Cycle and Migration
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Cell Cycle Cell cycle phases: G1, S, G2, M Cell proliferation is controlled by internal and external signaling molecules: mitogens and mitotic inhibitors. Mitogen : promoting progenitor cells to reenter the S phase of the cell cycle. Mitotic inhibitor : induce progenitor cells to exit from the cell cycle. The final number of neurons and glia in the mature nervous system is the summation of cell proliferation and programmed cell death. In C. elegans, regulation of cell divisions is not dependent on interactions with surrounding cells but rather is an intrinsic property of cell lineage.
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Cell Cycle Cyclins and cyclin- dependent kinases (CDK) control cell cycle The critical step during cell cycle is the transition from G1 to S phase. CyclinD and cdk4/cdk6 important for G1 phase to S phase transition G1 phase is cell growth period Cdc2 is CDK1, promote M phase (mitotic, cell division)
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Vertebrate Neural Tube Cell Cycle Ependymal zone: near the ventricle, cells in M phase Mantle zone: cells at S phase Marginal zone: containing axonal processes Nuclei migration M phase S phase
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Nuclei Migration S phase: DNA replication 3 H-thymidine injection into embryo to label S phase cells. Within 1 hr, labeled cells are all in the outer part of the ventricular zone, away from the ventricle. After 4 hr of injection, labeled cells all in the ventricular zone. The number of labeled mitotic figures increased. Postmitotic neurons migrate from the ventricular zone to the marginal zone to continue their differentiation. Cell cycle length ~8 hrs here G1 – S – G2 – M phase Cell cycle length
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Cell cycle length increases progressively during embryogenesis. G1 phase increases significantly during development, possibly due to a regulatory process by growth factors restricting re-entry into S phase from G1 phase. G2 and M phase almost
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This note was uploaded on 08/26/2011 for the course BIOL 426 taught by Professor Profgongchen during the Spring '08 term at Pennsylvania State University, University Park.

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10-Cell_cycle_and_migration - Cell Cycle and Migration Cell...

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