11-Determination_and_Differentiation

11-Determination_and_Differentiation - Cell Fate...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Cell Fate Determination and Differentiation
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Intrinsic and Extrinsic Determinants Cell fate is determined by both intrinsic and extrinsic factors. Intrinsic factor: programmed genes turned on and off and lead to certain cell fate. Extrinsic factor: signals released by neighboring cells to turn on and off genes and lead to certain cell type. Extrinsically determined
Background image of page 2
Testing Extrinsic Factors RA, Shh Noggin Chordin
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
C. Elegans Lineage C. Elegans cell fate is mainly determined by intrinsic factors.
Background image of page 4
Intrinsic Determinants in C. Elegans mutant mutant Q1.p Reverse to Mother Q Touch cell Needs mec-3 neuroblast Gene Control Hierarchy: Unc-86 Controls Mec-3 Together Controls Mec-7, mec-12, Mec-17 etc mutant Functional defect
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Neuroblast Lineages in Drosophila Each neuroblast expresses a distinct set of markers and gives rise to a specific set of neurons and glia A neuroblast in a specific position always generates GMCs that produce the same group of neurons Neuroblasts transiently express temporally coordinated transcription factors Hb, then Kr, then Pdm, then Cas. Hb- or Kr- mutants miss corresponding GMCs; Maintain HB or KR keep the early form of GMCs
Background image of page 6
Asymmetrical Division Asymmetric division: Intrinsic effect Different factors (Numb, Miranda, and Inscuteable) are located in opposite poles to promote asymmetric division
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Asymmetrical Division Green: Numb Red: chromosome Numb localize to one side and then restricted to only one cell (GMC) after asymmetric cell division. The remaining neuroblast
Background image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 08/26/2011 for the course BIOL 426 taught by Professor Profgongchen during the Spring '08 term at Pennsylvania State University, University Park.

Page1 / 31

11-Determination_and_Differentiation - Cell Fate...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online