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3 types of refinement

3 types of refinement - 3 types of refinement Topography...

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3 types of refinement: Topography, convergence, and postsynaptic compartment Synaptic refinement: 1. Increase specificity 2. Mediate Experience-dependent plasticity Refinement in Lateral Geniculate Nucleus First refinement: Eliminate branches in the wrong layer Second refinement: Further prune extra branches in the correct layer Monocular and Binocular Neurons Monocular neurons: cortical neurons responding to only one eye. Mainly in layer IV. Binocular neurons: majority of cortical neurons outside layer IV respond to both eyes. Binocular Deprivation Turns wiring back to normal Suggest that competition is necessary for synapse elimination in monocular deprivation. Similar competition applies to cortical-spinal projections as well. Synaptic Competition Hypothesis Co-activated synapses are stabilized; Inactive synapses, particularly those that are inactive while others are active (firing action potentials), become weakened and in many cases eliminated. The more the use, the stronger it is. Strabismus: Competition Depends on Timing In strabismic kittens, visual stimuli activate different positions on the two retinas, so that cortical neurons are rarely activated by both eyes at the same time.
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