20-Synaptic_refinement - Synapse Formation Part II:...

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Synapse Formation Part II: Synaptic Refinement Visual cortex: Hubel and Wiesel
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Three Types of Refinement Synaptic refinement: 1. Increase specificity 2. Mediate Experience- dependent plasticity
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Decreased Convergence After Maturation In mature target, there are less number but more precise innervation. Record postsynaptic potentials
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Ocular Dominance Columns in Visual Cortex Autoradiogram Two eye retinal projections alternate in cat primary visual cortex layer 4 neurons. Ocular dominance columns form gradually during development. Left eye Right eye
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Refinement in Lateral Geniculate Nucleus First refinement: Eliminate branches in the wrong layer Second refinement: Further prune extra branches in the correct layer
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Monocular neurons: cortical neurons responding to only one eye. Mainly in layer IV. Binocular neurons: majority of cortical neurons outside layer IV respond to both eyes. Hubel and Wiesel won Nobel Prize for their work on visual cortex responses.
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This note was uploaded on 08/26/2011 for the course BIOL 426 taught by Professor Profgongchen during the Spring '08 term at Pennsylvania State University, University Park.

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20-Synaptic_refinement - Synapse Formation Part II:...

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