21-Synapse_formation--current_research

21-Synapse_formation--current_research - Current Research...

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Current Research on Central Synapse Formation
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Topics: Glutamatergic synapse formation: A. Presynaptic differentiation B. Postsynaptic differentiation GABAergic synapse formation: Research in my lab
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Glutamatergic Synapse Formation Presynaptic differentiation
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FM imaging http://physiologyonline.physiology.o rg/content/16/1/10/F1.large.jpg
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New Presynaptic Bouton Appear within 2 hrs Friedman et al., Neuron, 2000 1 st label 2 nd label FM 1-43 imaging Identify presynaptic functional bouton
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Bassoon: Presynaptic Active Zone Protein Presynaptic protein bassoon precedes postsynaptic protein SAP 90 during new synapse formation
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Sequence of appearance of pre- and postsynaptic proteins
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For glutamatergic synapses, presynaptic differentiation precedes postsynaptic development
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Piccolo Developmental Distribution Assembling the Presynaptic Active Zone: A Characterization of an Active Zone Precursor Vesicle Rong Grace Zhai 1, Hagit Vardinon-Friedman 2, Claudia Cases-Langhoff 1, Birgit Becker 3, Eckart D. Gundelfinger 3, Noam E. Ziv 2, and Craig C.
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