1-423-08FAOx - = 7 FADH 2 , 7 NADH, 8 acetyl-CoA-7 FADH 2 =...

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2 Triacylglycerols: -glycerol -three fatty acids Stearic acid: 18:0 Linoleic acid: 18:2( Δ 9,12 ) Palmitic acid: 16:0 Stearic acid :18:0 Oleic acid: 18:1 ( Δ 9 )
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3 Usually Triacylglycerols Bile salts act as detergents Lipases are lipid- degrading enzymes
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4 Adipocyte: = fat storage cell Adipocyte: = fat storage cell
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5 FATTY ACID DEGRADATION 1. Fatty acid activation 2. Transport into matrix 3. β - oxidation
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6 FATTY ACID ACTIVATION (OMM ) Fatty acid + CoASH + ATP -> fatty-acyl-CoA + AMP + 2 Pi Transport of fatty-acyl CoA into matrix Carnitine acyltransferase I * Carnitine acyltransferase II ** Acyl Carnitine/carnitine transporter ## * ** ##
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7 OVERVIEW: β -oxidation -in mitochondrial matrix -cuts off 2-C pieces (acetyl CoAs) -1 FADH 2 , 1 NADH per cut THE POINT? -make reduced e- carriers -make acetyl-CoA 4 Steps of β -oxidation Oxidation Hydration Oxidation Thiolysis
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8 FADH 2 from β -oxidation? 2 ATP/ FADH 2 NADH from β -oxidation? 3 ATP/ NADH Each acetyl CoA from β -oxidation? 12 ATP/acetyl CoA
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9 Total up ATP yield for breakdown of palmitic acid (16:0) -7 rounds of beta oxidation
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Unformatted text preview: = 7 FADH 2 , 7 NADH, 8 acetyl-CoA-7 FADH 2 = 14 ATP-7 NADH = 21 ATP-8 acetyl-CoA through CAC= 8 (12) = 96 ATP-Sum = 131 ATP-Must subtract 2 ATP that were used to activate palmitic acid to palmitoyl CoA back in first step of degradation-NET 129 ATP per 16 carbon, saturated fatty acid. LOGIC OF REGULATION: WHERE TO CONTROL?-at level of entry of FA into matrix 10 Malonyl CoA inhibits carnitine acyltransferase I (X) X (Why Malonyl CoA? It is the first product in FA synthesis) Ketone bodies 11 Starvation/Diabetes Under conditions of starvation, uncontrolled diabetes:-Ketone bodies made in liver mitochondria-Excess acetyl CoAs added together, frees CoASH The point?-Frees up CoASH, allows -oxidation to continue-Makes something useful that is exported from liver * 12 Ketone bodies are transported from liver cells to muscle, brain In muscle, brain tissues, ketone bodies are degraded to acetyl-CoA, used in CAC in these tissues...
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This note was uploaded on 04/05/2008 for the course BIOCHEM 423 taught by Professor Osgood during the Spring '08 term at New Mexico.

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1-423-08FAOx - = 7 FADH 2 , 7 NADH, 8 acetyl-CoA-7 FADH 2 =...

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