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Behavioral Genetics

Behavioral Genetics - Gene Transcription in different...

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Behavioral Genetics-Remote Evolutionary Causes1-3 Level 3-Genomic Causes of Behavior—end point of evolution, (age, sex, and, species specific), starting point of life cycle, life long influences Developmental Genes C. elegans versus Human (18k-23k) Cascade of regulatory elements in a hierarchical genome DNA structure and replication (a person is a gene’s way of making another gene) Peptide and Protein Synthesis Transcription factors (CAMS and SAMS, hormones and neurotransmitters, enzymes, membrane channels, receptors and transporters Serotonin and depression Dopamine transmitter and cocaine NMDA receptor-Rec. site for Na and Ca-genetically altered to make smarter mice brain organization and genes Fetal brain and homeobox genes CAMS and SAMS and genetic guidance-competition of role and activity Mutations-drop-outs, abnormalities of migration, and failure to form specific synapses Rapid evolution of RNA associated with cortical development-HAR1
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Unformatted text preview: Gene Transcription in different hemispheres Limitations on Genes—Overproduction of cells and connections, selective stabilization of synapses, neuronal group selection, sensitivity to initial conditions (chaos)—(pruning back cell death overproduction) Neuronal Group Selection-genes direct formation of local assemblies; networks survive or die depending on experience but also genetic landscape Huntington Gene, Cystic Fibrosis, PKU—blocks tyrosine synthesis and so phenylalanine builds up; toxic to neurons but diet change drastically changes effects Genes in Mood Disorders i.e. MDI if it was MEndelian Inheritance if eliminated maybe we would lose the crazies and the cool people Psychopathology and paths to illness Genes involved in suite of “normal” behaviors” Worriers, gay gene?, Genes and Instructive Anomaly...
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