153A_Exam2_W10_answers - Chemistry and Biochemistry 153A,...

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Chemistry and Biochemistry 153A, Winter 2010 Exam 2 Answers 1. False 2. True 3. True 4. False 5. True 6. a, c 7. b 8. Coordinates heme iron (proximal his) H-bonds to oxygen (distal his) Reduces binding affinity of CO (distal his) Stabilizes BPG binding to T-state (through salt bridges with His2 and His143 of β-chains) Forms (stabilizing) salt bridges in T-state (His146 of β-chains) (Additional answers may also be correct) 9. Myoglobin facilitates diffusion of O 2 through muscle 10. Mb p50 is lower than Hb p50. Myoglobin must be able to pick up (bind) O 2 at partial pressures where hemoglobin is releasing O 2 , so it must have a higher O 2 affinity (and lower p50). 11. False 12. True 13. True 14. True 15. True 16. False 17. a, (d), g 18. a. 18. b. The catalytic efficiency would be greater for hydrolysis of the peptide, because the peptide would bind the enzyme more tightly (in the specificity pocket and elsewhere – p -nitrophenylacetate doesn’t bind in the specificity pocket). This would lower Km and
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This note was uploaded on 08/26/2011 for the course CHEM 153A taught by Professor Staff during the Spring '05 term at UCLA.

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