153A_midterm2_W09

153A_midterm2_W09 - Chem 153A Winter 2009 Midterm Exam2 ID A-1 1(1 pt Write your exam ID(A-1 in the blank at the upper right of your answer sheet

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Chem 153A, Winter 2009, Midterm Exam2, ID: A-1 1/7 1. (1 pt) Write your exam ID ( A-1 ) in the blank at the upper right of your answer sheet. 2. (10 pts) True or False a. The free energy of the highest-energy intermediate directly determines the rate of a reaction. b. K I is equivalent to the K d of an enzyme-inhibitor complex. c. Some enzymes are regulated by how much substrate is present. d. In cumulative feedback inhibition, a pathway product can partially inhibit the activity of an enzyme in the pathway. e. In the concerted model of homotropic positive cooperativity, the binding of substrate yields a higher-affinity (or more active) state of the enzyme. 3. (3 pts) Which one of the following is not true? a. Enzymes act on and produce specific stereoisomers. b. Enzymes can be subject to multiple types of regulation. c. Enzymes function over a wide range of reaction conditions. d. Enzymes can potentially catalyze many different types of reactions. e. Enzymes can achieve higher rates of catalysis than chemical catalysts. 4. (10 pts) List all possible results that can be produced by each type of inhibitor: a. Competitive b. Mixed c. Noncompetitive d. Uncompetitive Choose from: 1. An apparent decrease in K m 2. An apparent increase in K m 3. No apparent change in K m 4. An apparent decrease in V max 5. An apparent increase in V max 6. No apparent change in V max
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Chem 153A, Winter 2009, Midterm Exam2, ID: A-1 2/7 5. (22 pts) You have discovered a new enzyme, metamorphase, which catalyzes the one- to-one conversion of caterpillic acid into mothrate. You analyze the kinetics of the enzyme by combining 0.8 nM metamorphase with varying concentrations of caterpillic acid, and measuring the rate of production of mothrate, as shown in the plots below. The equations on each plot describe the dotted line that traces the initial slope of each curve.
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Chem 153A, Winter 2009, Midterm Exam2, ID: A-1 3/7 (Question 5 continued) a. Draw a Lineweaver-Burk plot for metamorphase acting on caterpilic acid. Label the axes with numerical values, labels, and units.
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This note was uploaded on 08/26/2011 for the course CHEM 153A taught by Professor Staff during the Spring '05 term at UCLA.

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153A_midterm2_W09 - Chem 153A Winter 2009 Midterm Exam2 ID A-1 1(1 pt Write your exam ID(A-1 in the blank at the upper right of your answer sheet

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