2-423-08Gluconeo

2-423-08Gluconeo - 1 Glycolysis 2 Down is glycolysis, Up is...

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Unformatted text preview: 1 Glycolysis 2 Down is glycolysis, Up is gluconeogenesis. Occurs in the cytosol of (mostly) liver cells, when there is a high demand for glucose by other tissues (brain, RBCs) and dietary intake is insufficient. 3 OAA Glyoxylate cycle: present in bacteria, plants 2 Acetyl CoA + NAD + + 2 H 2 O---> OAA + 2 CoA + NADH + H + BUT Acetyl CoA is NOT a gluconeogenic precursor in mammals 4 Net Rxn of Gluconeogenesis 2 pyruvate + 4 ATP + 2 GTP + 2 NADH glucose + 4 ADP + 2 GDP + 6 P i + 2 NAD + 5 Seven reactions the same Three bypasses (guess which enzymes need to be bypassed?) + GTP + GDP + GTP MA shuttle in reverse + ATP First bypass 5 Seven reactions the same Three bypasses (guess which enzymes need to be bypassed?) + GTP + GDP + GTP MA shuttle in reverse + ATP First bypass 6 Why passing through mitochondria? 1) NADH + H + concentration in mitochondria is 100,000 times higher 2) Gluconeogenesis depletes cytosolic NADH resources....
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2-423-08Gluconeo - 1 Glycolysis 2 Down is glycolysis, Up is...

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