This preview shows pages 1–3. Sign up to view the full content.
This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: B iochemis ry E duca ion Department of iochemistry & Molecular iology University of New Mexico BIOC 423 Int oducto y Biochemist y Complex Lipids OBJECTIVES Be able to recognize and draw the structures of o phosphatidic acid o phosphatidylserine o phosphatidylinositol o phosphatidylethanolamine o phosphatidylcholine o di- and triacylglycerols Be able to outline three different synthetic approaches to make phospholipids o Activation of the polar head group and transfer to diacylglycerol o Activation of diacylglycerol and transfer to polar head group o Polar head group exchange Be able to recognize the structure of sphingosine and ceramide. Know generally how ceramide is converted into sphingomyelin, cerebrosides and gangliosides. Don't memorize pathways but do know the starting materials for synthesis Know how different moieties of glycerophospholipids are removed by phospholipases. Recognize a prostaglandin and know the reaction inhibited by aspirin OUTLINE Classes of phospholipids Phosphatidylethanolamine (PE) Phosphatidylcholine (PC) Phosphatidylserine (PS) Phosphatidylinositol (PI) Phosphatidylglycerol (PG) Catabolism Classes of sphingolipids ceramides cerebrosides gangliosides Catabolism Prostaglandin Structure Cyclooxygenase LECTURE Up to this point in the course we have discussed lipids in only two different contexts: 1) either as a storage form of energy (triacylglycerols) or as a component of membranes (amphipathic lipids primarily phospholipids). This is clearly an oversimplification of the functions that lipids play in metabolism and health. With the lipids we will encounter a large number of biological activities that range from structural, to detergents, to endocrine, paracrine and autocrine hormones, as well as signal transduction molecules. Whereas glycolysis, CAC, nitrogen transport, and fatty acid oxidation were studied in great detail, with the complex lipids we are not expecting the same level of detail. You should be able to recognize structures of the lipid classes and have a general idea of the synthetic approaches and catabolic scheme. As usual, important regulatory reactions will be pointed out as will reactions with significant effects on health and disease. PHOSPHOLIPIDS Structure: The generic structure below is representative of all phospholipids. In all cases a diacyl glycerol phosphate (phosphatidic acid) moiety is coupled to an alcohol of a polar head group by a phosphate ester linkage. What differs between the different classes of phospholipids is the nature of the polar head group. POLAR HEAD GROUP PHOSPHOLIPID Ethanolamine Phosphatidyl ethanolamine Choline Phosphatidyl choline Serine Phosphatidyl serine Inositol Phosphatidyl inositol Glycerol Phosphatidyl glycerol You should note that for phosphatidyl glycerol the polar head group could be a part of another phosphatidic acid in which case the molecule is called a diphosphatidyl glycerol or cardiolipin....
View Full Document
This note was uploaded on 04/05/2008 for the course BIOCHEM 423 taught by Professor Osgood during the Spring '08 term at New Mexico.
- Spring '08
- molecular biology