5-423-08CACRegGlyox

5-423-08CACRegGlyox - intermediates The point? To generate...

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1 Pyruvate dehydrogenase complex 4C 6C 2C 6C 5C 4C 4C 4C 4C
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2 Overall, two C atoms enter cycle as an acetyl group and exit as CO 2 which requires four oxidation steps that generate 3 NADH and 1 FADH 2 NET REACTION Acetyl CoA + 3 NAD + + FAD + GDP + Pi + 2 HOH => 2 CO 2 + 3 NADH + FADH 2 + GTP + 3 H + + CoA No net formation or use of any of the 4,5,6-C intermediates The point? To generate ATP, NADH, metabolic intermediates YES, YOU NEED TO KNOW ALL THIS…
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3 An oxidative decarboxylation
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4 * If Δ G’ o is positive, how can the reaction go forward???? An oxidative decarboxylation
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5 An oxidative decarboxylation A substrate level phosphorylation
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6 An oxidation Part of ETC
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7 An oxidation * NET REACTION Acetyl CoA + 3 NAD + + FAD + GDP + Pi + 2 HOH => 2 CO 2 + 3 NADH + FADH 2 + GTP + 3 H + + CoA No net formation or use of any of the 4,5,6-C
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Unformatted text preview: intermediates The point? To generate ATP, NADH, metabolic intermediates Aerobic process (though no O 2 directly used) 8 LOGIC OF REGULATION: WHERE TO CONTROL? Overview: control occurs at points you would guess-1st reaction-reactions with large negative G o values 9 An oxidative decarboxylation WHY would these inhibit, activate??? Pyruvate Dehydrogenase is also regulated by reversible phosphorylation: [ATP] controls this PDH PDH High 10 11 * Biosynthetic role of CAC *Pyruvate carboxylase provides replacement: Pyr + CO 2 + ATP + H 2 O----> OAA + ADP + Pi 12 Glyoxylate cycle: present in bacteria, plants 2 Acetyl CoA + NAD + + 2 H 2 O---> OAA + 2 CoA + NADH + H + From Fatty acid breakdown...
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This note was uploaded on 04/05/2008 for the course BIOCHEM 423 taught by Professor Osgood during the Spring '08 term at New Mexico.

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5-423-08CACRegGlyox - intermediates The point? To generate...

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