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4-423-08GlycolysisRegStudent - Regulation of Glycolysis...

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Regulation of Glycolysis Objectives -Know which reactions in the glycolytic pathway are not readily reversible, and why. -Be able to describe the details of the control of glycolysis through the regulation of the enzymes hexokinase, PFK-1, pyruvate kinase -Be able to describe the LOGIC of these regulation mechanisms (For example, why does it make sense that high [ATP] inhibits glycolysis?) -What is an isozyme? How are hexokinase and glucokinase similar and different? -Review allosterism. How are the kinetic plots of allosteric enzymes different from those of simple enzymes? OUTLINE I. Overview Why is it important to control a metabolic pathway? -Glucose has other roles besides just being the starting point for glycolysis As the central pathway for both carbohydrate energy conversion and biosynthesis glycolysis must receive feedback from both catabolic and anabolic pathways. Control of the pathway resides in not all of the participating enzymes, but in only a few key enzymes. In general, enzymes that catalyze thermodynamically irreversible (in the cell) reactions are major regulatory points. There are three such enzymes in glycolysis: hexokinase, phosphofructokinase I, and pyruvate kinase II. Hexokinase A. Subject to feedback allosteric inhibition
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