3-423-08Glycolysis

3-423-08Glycolysis - 1 2 3 How to keep it all straight What...

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Unformatted text preview: 1 2 3 How to keep it all straight What does the overall pathway DO? What does it start, end with? Where does it occur? Get progressively more complicated (details like structures, enzymes, cofactors) End up with connecting these facts to all the rest (glycolysis connects to CAC how?) Focus on REGULATION Don't lose track of the forest in an appreciation of the millions of leaves. 4 * 5 6 7 The net result of steps 1-5 is conversion of glucose (6 C) into 2 molecules of glyceraldehyde-3-phosphate (3 C) with the expenditure of 2 ATP. 8 9 6 and 7 are coupled reactions, an energetically unfavorable + a favorable reaction: 1,3 BPG is common intermediate 10 11 Net glycolysis reaction: Glucose + 2 Pi + 2 ADP + 2 NAD+ ======> 2 pyruvate + 2 ATP + 2 NADH + 2 H+ + 2HOH So: what is the point of glycolysis? -to make ATP -to make NADH (in aerobic organisms, a source eventually of more ATP) -to make pyruvate, in aerobic organisms the lead-in to the next stage of catabolism, the CAC Possible fates of pyruvate 12 The point...regenerate NAD+ The point...regenerate NAD+ 13 14 LACTOSE 15 ...
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This note was uploaded on 04/05/2008 for the course BIOCHEM 423 taught by Professor Osgood during the Spring '08 term at New Mexico.

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3-423-08Glycolysis - 1 2 3 How to keep it all straight What...

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