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1-423-08Membranes - Behavior of amphipathic lipids in...

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Behavior of amphipathic lipids in aqueous solution Bilayers NOT very permeable to ions and polar molecules
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Membranes are not simply lipid bilayers… Fluid mosaic model Membranes are asymmetric… Membranes are fluid…what factors important in fluidity? …Length and degree of saturation of fatty acid tails of membrane phospholipids
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Longer = less fluidity (higher melting temperature) More saturated = less fluidity (higher melting temperature)
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Also, sterol molecules in membranes affect membrane fluidity Temperature of surroundings affect membrane fluidity
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Positions of membrane proteins Integral membrane proteins are often α -helical through the membrane
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Energetic considerations Transporters (carriers): overview -Show conformational changes -Active, passive -Process called membrane transport or carrier-mediated diffusion
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Transport is similar to enzymes-substrate reactions: -Binding is stereospecific -Binding occurs through weak, noncovalent interactions, at a binding site analogous to an active site
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