How Enzymes Catalyze Reactions Reaction ThermodynamicsOBJECTIVES • Be able to predict the spontaneity of a chemical reaction from the free energy change. • Define the relationship between standard free energy and the equilibrium constant. • Understand the differences between ΔG, ΔGoand, ΔGo’. • Describe the common features of the active sites of enzymes. • Describe how enzymes accelerate the rate of reactions. •Compare and contrast thermodynamics in closed and open systems. Define steady state. •Be able to calculate ΔG0’ for coupled reactions given the standard free energies OUTLINECatalysts Differences between enzymes and other catalysts Measuring enzyme activity Reaction thermodynamics Reaction progression Gibbs Equation Steady state reactions or open systemsHow enzymes functionCatalytic mechanisms Naming enzymes Coupled Reactions
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