02 Molecules - UNM Biochemist y ducation Depa tment of...

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Unformatted text preview: UNM Biochemist y ducation Depa tment of Biochemist y & Molecula Biology BIOC 423: I tr duct ry Bi chemistry The Building Blocks Properties and Structures of Biological Molecules OBJECTIVES Be able to: recognize and draw structures of the 20 common amino acids; know the 3-letter abbreviation for each classify the amino acids (nonpolar, polar and uncharged), understand how the amino acid side chain will interact in aqueous solution describe the acidic and basic nature of amino acids; be able to draw and/or decipher titration curves; given any pH you should be able to assign a charge to any of the 20 amino acids. understand disulfide bond formation define and be able to calculate pI based on structural formula, recognize amino acid, carbohydrate, lipid classes and nucleic acid and describe the behavior in water of all the different categories of biomolecules describe the functional roles of carbohydrates describe the different functional roles of nucleotides describe the biological functions of the major lipid classes OUTLINE Overview of biomolecules - Biopolymers Proteins monomers are amino acids Carbohydrates monomers are monosaccharides Lipids complexes with fatty acids and other hydrophobic molecules Nucleic acids monomers are nucleotides Amino Acid Structure Classification Chemistry of the side chain Acid Base behaviors Biological Functions Carbohydrates Structure Aldoses and Ketoses (reducing and non-reducing sugars) Structural representations Monosaccharides Polysaccharides; Glycosidic Bonds Biological Functions Nucleic acids Structure Base / Nucleoside / Nucleotide N-glycoside, phosphate ester, phosphate anhydride bonds Common purines and pyrimidines ATP structure Biological Functions Lipids Structure Non-polar lipids Polar lipids Properties of amphipathic compounds Biological Functions LECTURE CONTENT Overview of Biomolecules - Biopolymers During this course we will be discussing two different categories of biological molecules. One category are the small molecules (MW < 500). Molecules in this category are generally referred to as metabolites and they are generally in the biological process of being changed. Either the molecule is a fuel molecule in a process in which energy is being extracted from it ( catabolism ), or the molecule is a building block in a process in which the molecule is used as a starting material for building bigger structures ( anabolism ). Minerals, cofactors, vitamins and signaling molecules are all included in the category and have important functions, which we will discuss, in metabolism . We will spend a great deal of time with the second category of biological molecules. These molecules are the biopolymers. They are all constructed by polymerizing the low molecular weight subunits called monomers . The four major types of biopolymers are outlined in the following table....
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02 Molecules - UNM Biochemist y ducation Depa tment of...

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