ENGINEERING DRUG DELIVERY-POWERPOINT

ENGINEERING DRUG DELIVERY-POWERPOINT - Engineering Drug...

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Engineering Drug Delivery Aron Deen Michael Matlock Brian Copeland Brett Covey Jenny Oberlag
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Purpose of This Project Design a slow release pill to deliver medicine Analyze the Market Propose a fabrication process and a business plan.
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Types of Dosage Forms Immediate release: – Dosage delivery begins as soon as pill is ingested Sustained release: – Any dosage form that provides medication over an extended time – Zero-order release Rate of drug release is independent of the amount of drug remaining in capsule or tablet
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Release Profiles
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Types of Sustained Release Delivery Systems ¾ Matrix drug dispersed homogeneously throughout a polymer matrix. Drug in the outside layer is exposed to the bathing solution is dissolved and diffuses out of the matrix ¾ Reservoir drug core surrounded/coated by a rate controlling membrane ¾ Osmotic utilize the principles of osmotic pressure for the delivery of drugs
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Matrix Release System
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Reservoir Diffusion Device
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Osmotic Pressure Chemical potential of solvent in a solution and a pure liquid must be the same if they are in contact through a semi-permeable membrane at the same pressure. h 1 2
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Push-pull Osmotic Pumps Delivery Orifice Push Layer Semipermeable Membrane Osmotic Drug Core Push Layer Semipermeable Membrane Osmotic Drug Core Before Ingestion After Ingestion
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Design Options Push layer polymer Semi-permeable membrane Size of delivery orifice Contents of drug layer Dimensions of tablet Thickness of semi-permeable membrane
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Push Layer Polymer Hydrogel Hydrophilic materials that swell in water due to presence of hydrophilic groups (like -OH, COOH, NH2, etc) or due to presence of ionic groups (like COO-, NR4+, etc).
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Φ = volume of water absorbed/volume of dry polymer t t v β = ) ( Constant Delivery Profile Swelling Ratio
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Materials present in the push layer swelling is linear with time cheap material to purchase does not react with the active ingredient 18.4 mg polyacrylic acid (PAA) hydrogel crosslinked with ethylene glycol dimethacrylate (EGDMA)
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Semi-permeable Membane Criteria High Water Permeability High degree of Semipermeabilily to solute Stability over a wide range of pH and temperatures Good mechanical integrity Life span of 3-5 years Biocompatible Low cost
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Membrane-forming Polymer Two major groups of polymeric materials have the right qualifications to produce satisfactory membranes for osmosis. Cellulose Acetate (CA) ¾ Ease of FDA approval
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Size of delivery orifice Smaller Diameters ¾ Development of Hydrostatic Pressure Inside the pill Larger Diameters ¾ Significant Diffusion
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