ENGINEERING DRUG DELIVERY-POWERPOINT

ENGINEERING DRUG DELIVERY-POWERPOINT - Engineering Drug...

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Engineering Drug Delivery Aron Deen Michael Matlock Brian Copeland Brett Covey Jenny Oberlag
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Purpose of This Project Design a slow release pill to deliver medicine Analyze the Market Propose a fabrication process and a business plan.
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Types of Dosage Forms ± Immediate release: – Dosage delivery begins as soon as pill is ingested ± Sustained release: – Any dosage form that provides medication over an extended time – Zero-order release • Rate of drug release is independent of the amount of drug remaining in capsule or tablet
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Release Profiles
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Types of Sustained Release Delivery Systems ¾ Matrix ± drug dispersed homogeneously throughout a polymer matrix. Drug in the outside layer is exposed to the bathing solution is dissolved and diffuses out of the matrix ¾ Reservoir ± drug core surrounded/coated by a rate controlling membrane ¾ Osmotic ± utilize the principles of osmotic pressure for the delivery of drugs
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Matrix Release System
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Reservoir Diffusion Device
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Osmotic Pressure Chemical potential of solvent in a solution and a pure liquid must be the same if they are in contact through a semi-permeable membrane at the same pressure. h 1 2
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Push-pull Osmotic Pumps Delivery Orifice Push Layer Semipermeable Membrane Osmotic Drug Core Push Layer Semipermeable Membrane Osmotic Drug Core Before Ingestion After Ingestion
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Design Options ± Push layer polymer ± Semi-permeable membrane ± Size of delivery orifice ± Contents of drug layer ± Dimensions of tablet ± Thickness of semi-permeable membrane
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Push Layer Polymer ± Hydrogel Hydrophilic materials that swell in water due to presence of hydrophilic groups (like -OH, COOH, NH2, etc) or due to presence of ionic groups (like COO-, NR4+, etc).
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Φ = volume of water absorbed/volume of dry polymer t t v β = ) ( ± Constant Delivery Profile Swelling Ratio
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Materials present in the push layer ± swelling is linear with time ± cheap material to purchase ± does not react with the active ingredient 18.4 mg polyacrylic acid (PAA) hydrogel crosslinked with ethylene glycol dimethacrylate (EGDMA)
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Semi-permeable Membane Criteria ± High Water Permeability ± High degree of Semipermeabilily to solute ± Stability over a wide range of pH and temperatures ± Good mechanical integrity ± Life span of 3-5 years ± Biocompatible ± Low cost
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