Engineering Lotion-Presentation

Engineering Lotion-Presentation - Engineering Lotion by...

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Unformatted text preview: Engineering Lotion by Season Hill Amanda Robben S R kin emedies, I nc. Purpose s Develop a moisturizing lotion to treat ichthyosis and xerosis s Design the manufacturing procedure for the lotion Agenda s The Skin s Skin Disorders s Treatment s Consumer Satisfaction Model s Demand Model s Manufacturing Process s Economic Analysis s Future The Skin The Skin s Functions as a barrier to provide immunity from disease s Repairs itself daily by replacing the outer layer s Contains three layers: epidermis, dermis and subcutaneous Source: http://cancer.healthcentersonline.com/skincancer/basalcellcarcinoma.cfm Epidermis s The outermost layer of skin s Composed of several layers r Stratum Corneum (1) is outermost layer of the epidermis Source: www.eucerim.co.uk Stratum Corneum s Interacts directly with environment s Approximately 20 cell layers thick s Location in which desquamation occurs r Desquamation is the shedding of the top layer of cells in the stratum corneum r Approximately 1 layer per day is released Stratum Corneum (cont.) s Contains hydrophilic cells surrounded by a hydrophobic lipid bilayer r The lipid bilayer prevents water removal from the skin to the atmosphere s Contains natural moisturizing factors (NMF) responsible for the absorption and retention of water r Water content is about 30% www.cerave.com/barrier.htm Skin Disorders Xerosis (Dry Skin) s Reduced water content in Stratum Corneum s Occurs when natural moisturizers on the skins surface are removed s Caused by overexposure to water, sun, or cold weather s Symptoms include dry, itchy skin Ichthyosis s Genetic disorders in the production and/or desquamation of cells r Rapid production of skin cells r Desquamation is slowed or inhibited s Results in dry and thickened, scaly skin s Incurable disorders Source: Geneva Foundation for Medical Education and Research, www.gfmer.ch Ichthyosis Vulgaris s Accounts for 95% of all ichthyosis cases s Affects 1 in 250 people s Caused by low water content in Stratum Corneum r The enzymatic reactions controlling desquamation are inhibited Source: www.ichthyosis.com Effects on Skin Barrier s Reduced or low water content in the Stratum Corneum results in a compromised barrier s This compromised barrier must be restored in order to prevent excessive water loss Compromised Barrier Intact Barrier Source: http://www.cetaphil.com.au/importance_of_your_skin_more.asp Treatment Current Treatment s Temporary and symptomatic s Primarily focus on supplying ingredients that replenish and retain water content s However, there are three key steps to effectively treat the disorders: 1) Promote desquamation 2) Deliver moisturizing agents to underlying skin 3) Restore the skins lipid bilayer Moisturizer Formulation s The simplest vehicle for skin moisturizers are emulsions s For lotions, oil-in-water emulsions are used r Water is the continuous phase r Oil is the dispersed phase Source: http://www.pg.com/science/skincare/Skin_tws_101.htm Moisturizer Formulation (cont.)Moisturizer Formulation (cont....
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Engineering Lotion-Presentation - Engineering Lotion by...

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