Engineering Skin Lotions-Presentation

Engineering Skin Lotions-Presentation - Integumentary...

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Integumentary Perfections Curtis Baade Shamara Manora
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Agenda 1. The Skin 1. The Skin 2. Product Design 2. Product Design 3. Economic Analysis 3. Economic Analysis 4. Conclusions 4. Conclusions
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The Skin Skin Layers
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The Skin Semi-permeable barrier between body and environment Contains three layers: epidermis, dermis and subcutaneous Source: http://cancer.healthcentersonline.com/skincancer/basalcellcarcinoma.cfm
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Epidermis The outermost layer of the epidermis is the stratum corneum Approximately 20 cell layers thick Location in which desquamation occurs Desquamation is the shedding of the top layer of cells in the stratum corneum Approximately 1 layer per day is released Source: www.eucerim.co.uk
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Stratum Corneum Contains hydrophilic cells (keratinocytes) surrounded by a hydrophobic lipid bilayer (lipid lamellae) Contains natural moisturizing factors (NMF) which are responsible for the absorption and retention of water. www.cerave.com/barrier.htm
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Effects on Skin Barrier Reduced or low water content in the Stratum Corneum results in a compromised barrier (chapping) This compromised barrier must be restored in order to prevent transepidermal water loss Compromised Barrier Intact Barrier Source: http://www.cetaphil.com.au/importance_of_your_skin_more.asp
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The Skin Skin Disorders
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Xerosis (Dry Skin) Natural moisturizers Stratum Corneum are removed Caused by overexposure to water, sun, or cold weather Symptoms include dry, itchy skin Source: University of California, San Fransico, www.uscf.edu
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Ichthyosis Vulgaris Incurable, genetic disorder affecting production and/or desquamation of cells Caused by low water content in Stratum Corneum enzymatic reactions controlling desquamation are inhibited Symptoms include dry, thickened, scaly skin Source: Geneva Foundation for Medical Education and Research, www.gfmer.ch
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The Skin Treatment Therapy
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Treatment Strategy Three key steps to effectively treat the disorders Promote desquamation Deliver moisturizing agents to underlying skin Restore the skin’s lipid bilayer
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Transdermal Diffusion Percutaneous absorption mostly occurs via transcellular diffusion (Pathway 2) Other pathways are Intercellular diffusion (Pathway 1) Diffusion through skin appendages (Pathway 2) keratinocytes lipid lamellae appendage (follicle or sweat duct) 12 3 Source: A Geoscience Approach to Modeling Chemical Transport Through the Skin
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Moisturizer Formulation The simplest vehicle for skin moisturizers are emulsions For lotions, oil-in-water emulsions are used Water is the continuous phase Oil is the dispersed phase Source: http://www.pg.com/science/skincare/Skin_tws_101.htm
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Lotion Composition Lotions have active and inactive ingredients Ingredients are characterized by a combination of properties (e.g. effectiveness, smoothness, thickness, etc.)
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Product Design Lotion Composition
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Product Regulations Since skin moisturizers are considered cosmetic products, they do not have to adhere to FDA regulations Cosmetics are subject to restrictions on the concentration of certain ingredients determined by the Cosmetic Ingredient Review Source: http: www.cfsan.fda.gov/~dms/cos-206.html
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Lotion Composition Replenish Skin’s Health HUMECTANTS EXFOLIANTS OCCLUSIVES EMOLLIENTS
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Lotion Composition Other Lotion Properties SOLVENTS PRESERVATIVES THICKENERS FRAGRANCE BUFFERS EMULSIFIER COLOR
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Product Design Customer Satisfaction Assessment
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Engineering Skin Lotions-Presentation - Integumentary...

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