Unformatted text preview: E XECUTIVE S UMMARY A human body simulator that mathematically models the concentration levels of a drug in the blood and in 23 tissues was developed. The model consists of over 1,100 simultaneous ordinary differential equations and two-hundred parameters. Case studies were performed which compared the model to experimentally obtained drug concentration data for two different drugs and showed that the model could reproduce experimental results extremely well. Developing a human body model is critical to the pharmaceutical industry where $70 billion is spent every year on research and development of new drugs. This money is mostly used for in vitro and in vivo testing of large numbers of compounds with potential medical applications, most of which are later found to be unsuitable for further development. A human body simulator should refine this process by allowing pharmaceutical companies to screen more compounds using simulations as opposed to expensive lab testing. Additional applications include allowing doctors to simulations as opposed to expensive lab testing....
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- Spring '10
- Chemical Engineering, Human Body, pharmaceutical companies, In vivo, human body simulator