Final presentation-Chondrocytes

Final presentation-Chondrocytes - N.K.O.B. (New Kim on the...

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N.K.O.B. ® (New Kim on the Block) Injectable Polymer Scaffolds – An Approach to Cartilage Tissue Engineering Mark Shreve, Jessica Yankovich, Mira Kim
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Background z Millions of Americans suffer from trauma, disease, or malformation of cartilage tissue z Cartilage provides { Mechanical support { Distributes forces during loading { Lubrication to the joint z Cartilage lacks the ability to regenerate itself z Current treatments are not seen with high success rates
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Project Aim z Goal { Regenerate cartilage in knee to restore full functionality in a minimally invasive manner z Pathway { Employ a procedure involving an injection of a biodegradable cell/scaffold/growth factor composite into defect site
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Cartilage Anatomy z Composed of four components { Chondrocytes z 10% of total volume of cartilage tissue { Collagen { Proteoglycans { Water z 80% of total volume of cartilage tissue Articular Surface Chondrocytes Calcified Zone Subchondral Bone Tide mark Superficial Zone (10-20%) Middle Zone (40-60%) Deep Zone (30%)
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Chondrocytes z Cartilage receives no neural impulses { No nerve supply { No vascular supply z Cannot signal repair
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Collagen z Macromolecule with triple helical structures z Type II is prevalent in articular cartilage z Gives cartilage shear and tensile properties z Maintains proteoglycan in extracellular matrix http://www.rcsb.org/pdb/molecules/pdb4_1.html
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Proteoglycan z Complex macromolecules { Long protein chain { 100s of bound glycosaminoglycans z Promotes proteoglycan-collagen and proteoglycan-proteoglycan interactions z Holds the tissue together z Gives mechanical properties
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Types of Cartilage z Fibrocartilage (type I) { Non-load bearing regions z Ear z Nose { Less resilient mechanical properties z Hyaline cartilage (type II) { Prevalent in all diarthroidal joints { Resilient mechanical properties www.silent.se/ soundscapes.php http://netscape.lhj.com/lhj/story.jhtml?storyid=/templatedata /bhg/story/data/6501.xml&catref=cat410032
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Cartilage Defects z Injury to articular cartilage { Cartilage lesions { Osteoarthritis z Cartilage lacks the inherent means to regenerate itself z Many cartilage defects affect underlying subchondral bone Ref: http://www.orthogastonia.com/patient_ed/html_pages/knee/knee_cartilage_surgery.html
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Cartilage lesions z Underlying bone is often exposed z May result in unbalanced joint z Leads to further damage with surrounding tissues http://www.carticel.com/patients/learning/aboutcartdamage.asp
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Osteoarthritis z Noninflammatory degenerative joint disease z Bones rub and underlying subchondral bone is warn away z Leads to further complications http://www.zimmer.com/ctl?op=global&action=1&id=1979&template=PC
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Current Therapies z Reparative { Temporary { Produces fibrocartilage z Arthroscopic debridement z Abrasion arthroplasty z Microfracturing http://www.orthogastonia.com/patient_ed/html_pages/knee/knee_cartilage_surgery.html
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Current Therapy z Restorative { Not highly successful { Chondrocytes migrate from defect site z Osteochondral autografts z Osteochondral allografts z Autologous chondrocyte implantation http://www.orthogastonia.com/patient_ed/html_pages/knee/knee_cartilage_surgery.html
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Final presentation-Chondrocytes - N.K.O.B. (New Kim on the...

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