Moisturizing Lotion-Presentation

Moisturizing Lotion-Presentation - Hemina Skin Rebuilding...

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Hemina Skin Rebuilding and Reconditioning Therapy: Treating Ichthyosis & Xerosis Heyde E. Lopez Monica Sanders Erin Sposato
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Purpose ± To design a moisturizing package that treats ichthyosis skin disorder and xerosis (dry skin) ± May target other skin disorders
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Agenda ± Anatomy ± The Skin Disorder ± Treatment ± Our Original Product ± Substitutes and Modeling Consumer Attitudes ± Demand Model ± Manufacturing ± Economic Analysis
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Anatomy
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The Human Skin ± Self-contained organ that exists as a semipermeable barrier layer ± Two components with interdependent functions: epidermis and dermis Source: www.healthzone.co.uk
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Epidermis ± ~40 µ m thick ± Four (or five) layers 1. Stratum corneum 2. (Stratum lucidium) 3. Stratum granulosum 4. Stratum spinosum 5. Stratum basale ± Basal membrane (6) Source: www.eucerim.co.uk
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Stratum Corneum ± Generally ~10-15 µ m thick ± Tough but pliable quality given by keratin ± 10–20 layers of corneocytes embedded in a matrix of lamellar lipids
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Stratum Corneum ± “Brick and mortar” structure ² Corneocytes (bricks) ± Anucleated, non-viable, keratin-rich cells ± Hydrophilic ² Lipid lamellae (mortar) ± Tight lateral packing ± Hydrophobic Source: www.pg.com Ceramides (40-50%) Cholesterol (25%) Fatty acids (10-15%) Other lipids, such as cholesterol sulfate (<5%)
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Stratum Corneum Cohesion ± Desmosomes - main cohesive forces ² Protein bridges ² Attach to cell envelopes and lock into position ± Covalent bonding of lipids in matrix ± van der Waals forces hold the lipid lamellae and the corneocytes Source: www.netwellness.org
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Desquamation ± Corneocytes break apart and are lost ± Enzymatic process – dissolves desmosomes ± These proteolytic enzymes are present in well- hydrated SC ± Defective desquamation - corneocytes build up
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Natural Moisturizing Factor ± High concentration inside the corneocytes ± Some in the intercellular lipid matrix ± Humectants - absorb water ± Allow for the outermost layers of the SC to remain hydrated
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Stratum Corneum Corneocytes Lipid Matrix NMF Components •Lactic acid •Urea •Urocanic acid •PCA •Citrates •Sugars Desmosomes
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Types of diffusion through skin ± Percutaneous difussion: Rate and extent that a chemical is absorbed into and through the skin ± Transepidermal water loss (TEWL) Passage of water from the body through the skin into the outside environment
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Percutaneous Diffusion Transcellular diffusion Corneocytes Lipid lamellae Intercellular diffusion Diffusion through appendages through the lipid lamellae through both the corneocytes and lipid lamellae (hair follicles and sweat ducts) SC is rate-limiting step *rate determining component of the SC barrier
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The Skin Disorder
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Xerosis ± Dry skin of a ‘normal’ or non-pathological state ± Low water content in SC ± Dry and itchy skin ± Occurs when natural moisture is drawn out ± Can be due to cold weather or exposure to too much water
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