Monoclonal Antibodies for Cancer Therapy -Presentation

Monoclonal Antibodies for Cancer Therapy -Presentation -...

Info iconThis preview shows pages 1–13. Sign up to view the full content.

View Full Document Right Arrow Icon
CCKK Drug Delivery Technologies
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
CCKK Drug Delivery Technologies: Monoclonal Antibodies for Delivery of Chemotherapy Drugs for Cancer Therapy Sarah Clawson Paul Cole Sarah Katen Nell Keith
Background image of page 2
Introduction ± Project Objective: Improve chemotherapy drug delivery for maximum efficacy with minimal side effects ± Disease Considered: Gliomas – common brain tumor ± Method of Delivery: Micelle and monoclonal antibody complex
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
What is a Monoclonal Antibody? ± MAb - an antibody that binds to a single epitope Stevens, Glen. Brain Tumors: Meningiomas and Gliomas . April 22, 2003. http://www.clevelandclinicmeded.com/diseasemanagement/neurology/braintumor/braintumors.htm Image Courtesy of: http://www.strayvr.com/FullyHuman.jpg ± In tumor cells the epitope is often a protein on the cell surface
Background image of page 4
Treatment Options Using MAbs Janeway, Charles A., et al. Immunobiology . 5th ed. New York: Garland Publishing, 2001.
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Production of Monoclonal Antibodies Janeway, Charles A., et al. Immunobiology . 5th ed. New York: Garland Publishing, 2001.
Background image of page 6
Immunogenicity in Humans ± Most MAbs are produced using murine (mouse) cells ± The human body may recognize the MAbs as being foreign. This can result in: ± Allergic reaction ± Failure of treatment Janeway, Charles A., et al. Immunobiology . 5th ed. New York: Garland Publishing, 2001.
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Engineering MAbs to Reduce Immunogenicity ± Graft the antigen binding loop of the mouse antibody to the framework of a human antibody ± MAb still has the same antigen/antibody binding specificity Janeway, Charles A., et al. Immunobiology . 5th ed. New York: Garland Publishing, 2001.
Background image of page 8
Malignant Gliomas Tumors ± Gliomas are the most common type of primary brain tumors in adults ± Anaplastic Astrocytoma (III) ± Glioblastoma Multiforme (IV) ± Conventional therapy: ± Surgery ± External-beam radiation ± Chemotherapy ± Median survival: 40-60 weeks A Primer of Brain Tumors . American Brain Tumor Association. 1991. <http://neurosurgery.mgh.harvard.edu/abta/primer.htm#Section6>
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
81C6 MAb ± 81C6 is a monoclonal antibody that binds to tenascin, a tumor-associated extracellular matrix protein ± Tenascin is found in: ± Gliomas ± Connective tissue (trace amounts) ± Developing organs (trace amounts) Cokgor, Ilkcan, et al. “Phase I Trial Results of Iodine-131-Labeled Antitenascin Monoclonal Antibody 81C6 Treatment of Patients With Newly Diagnosed Chiquet-Ehrismann, Ruth. What Distinguishes Tenascin From Fibronectin ? The FASEB Journal . Vol. 4. June 1990.
Background image of page 10
Blood Brain Barrier ± Tight junctions in capillary endothelial cells that prevent molecules from entering into glial cells ± Entry is achieved by a molecule’s solubility in lipids or by transporters Purves, Dale, et al. Neuroscience . 2 nd ed. Sinauer Associate, Inc. 2001. Image courtesy of http://homepage.psy.utexas.edu/homepage/class/Ps y332/Salinas/Cells/BBB.gif
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
How can the Blood Brain Barrier be overcome?
Background image of page 12
Image of page 13
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 08/31/2011 for the course CHE 4273 taught by Professor Staff during the Spring '10 term at Oklahoma State.

Page1 / 74

Monoclonal Antibodies for Cancer Therapy -Presentation -...

This preview shows document pages 1 - 13. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online