Saliva Diagnostics-Presentation

Saliva Diagnostics-Presentation - Saliva Diagnostics for...

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Saliva Diagnostics for Kidney Disease May 3, 2007
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5/2/2007 2 Overview • Advantages of Saliva Diagnostics • Background • FDA Approval • Consumer Satisfaction • Consumer Preference • Pricing and Demand • Net Present Worth
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5/2/2007 3 Alternative to Blood Testing • Saliva contains many of the components of blood – In much lower concentration – Mostly items that passively diffuse through salivary glands • Collecting saliva is much less invasive and faster – Reduces risk of exposure for health care professional – Saliva has fewer components that interfere with assay, reducing steps needed in analysis • Some people refuse blood testing for cultural or religious reasons
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5/2/2007 4 The Beginning of Saliva Diagnostics • Microfluidics Microfluidics Microfluidics – A new field which began in the early 90’s – Combination of physics, chemistry, biotechnology, and engineering – Develops a better understanding of how fluids move on a micro and nanoliter scale • Allows for the design of more sensitive diagnostic devices
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5/2/2007 5 Current State of Saliva Diagnostics • Conditions presently being assessed using saliva – Alcohol consumption – Drug use – Hormone levels – HIV 1 and 2 – Viral hepatitis A, B, and C • Current research – Cardiovascular disease – Cancer – Alzheimer’s – Osteoporosis
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5/2/2007 6 Saliva • Saliva has many components – Mostly water with some mucus – A variety of electrolytes (K + , Na + , Cl - , Ca + ) • Many proteins found in blood also make their way into saliva
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5/2/2007 7 Saliva Composition • 98% water • Electrolytes – Sodium ~32 mmol/L – Potassium ~22 mmol/L – Calcium ~1.7 mmol/L – Magnesium ~0.18 mmol/L – Copper ~0.4 μ mol/L – Lead ~0.55 μ mol/L – Cobalt ~1.2 μ mol/L – Strontium ~1 μ mol/L – Hydrogen Carbonate ~20 mmol/L – Iodide ~10 μ mol/L – Bromide ~14 mmol/L – Hypothiocyanate ~1.2 μ mol/L – Nitrate ~1.1 μ mol/L – Nitrite ~178 μ mol/L – Fluoride ~68 μ mol/L – Sulfate ~5.8 μ mol/L • Mucus – Mucopolysaccharides – Glucose ~175 μ mol/L • Metabolites – Bilirubin ~15 μ mol/L α -ketoglutaric acid ~2.4 μ mol/L – Pyruvic acid ~75 μ mol/L • Proteins α -amylase ~650-800 μ g/ml – Peroxidase ~5-6 μ g/ml – Secretory IgA ~96-102 μ g/ml – Lactoferrin ~1-2 μ g/ml – Fibronectin ~0.2-2 μ g/ml • Cells
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8 Our Screening Procedure Can biomarker be detected in saliva Abnormal levels indicate threat of organ malfunction How do you detect abnormal levels How accurate are detection methods How widely applicable are detection methods • How helpful is result in medical decision making • Is test effective in early diagnosis (compared to serum testing) • Weigh accuracy vs. speed, convenience,
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This note was uploaded on 08/31/2011 for the course CHE 4273 taught by Professor Staff during the Spring '10 term at Oklahoma State.

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Saliva Diagnostics-Presentation - Saliva Diagnostics for...

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