05CellularRespiration11Sp

05CellularRespiration11Sp - Biology 6B 05 Cellular...

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1 Chapter 9 Cellular Respiration Food: energy in chemical bonds. Free the electrons: exergonic. How can energy be captured in usable form? Respiration Overview ATP is the usable energy form for most processes. Respiration Overview How do you make it? The Hindenburg explosion: An exergonic redox reaction 2 H 2 +O 2 2 H 2 O a redox process a redox process Biology 6B 05 Cellular Respiration Brian McCauley Spring 2011
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2 Cell structure controls cell function. You are not a blimp: Hindenberg: 1 redox step; energy released as light & heat. Respiration: many redox steps; redox powers H + gradient; H + gradient powers ATP synthase. Facilitated diffusion of protons drives ADP phosphorylation to make ATP. ATP Synthase Oxidative phosphorylation Respiration mechanisms Harvesting electrons from food: glycolysis & the citric acid cycle. Making the proton gradient: electron transport chain. Using the proton gradient to power ATP synthesis: oxidative phosphorylation. Glycolysis: Cytosol. Glucose split & partially ozixidized, 2 pyruvate. NADH. ATP. Harvesting electrons Biology 6B 05 Cellular Respiration Brian McCauley Spring 2011
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3 Substrate-level phosphorylation Glycolysis summary Phosphorylation increases free energy of glucose. High-energy e - moved to NADH. 2 net ATP. Mycoplasma genitalium Metabolic pathways of a minimal bacterium Respiration roadmap Pyruvate transport & conversion to acetyl Pyruvate / H + symporter mitochondrial matrix Pyruvate inter- membrane space cytosol Pyruvate moves down its concentration gradient into intermembrane space. porin Biology 6B 05 Cellular Respiration Brian McCauley Spring 2011
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4 Pyruvate / H + symporter mitochondrial matrix Pyruvate inter- membrane space cytosol H + Proton gradient drives cotransport of pyruvate & H + into matrix Glucose gets split into 2 pyruvate in glycolysis (in cytosol). Pyruvate gets partially oxidized to acetyl (in mitochondrion). Acetyl gets fully oxidized in the citric acid cycle (in mitochondrion).
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05CellularRespiration11Sp - Biology 6B 05 Cellular...

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