07MolecularGenetics11Sp

07MolecularGenetics11Sp - What does DNA do? DNA, Genes,...

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Unformatted text preview: What does DNA do? DNA, Genes, & Gene Expression Ch. 16: DNA DNA Structure: 3 Models Nucleic Acid Components Base Pairing is Specific Each strand serves as a template for a new strand. DNA Replication DNA strands are complementary and antiparallel. DNA Replication Biology 6B 07 Molecular Genetics Brian McCauley Spring 2010 Nucleotides are added to the 3’ end Nucleotides are added to the 3’ end Bacterial DNA Replication Bacterial DNA Replication origin of replication replication fork Eukaryotic DNA Replication replication fork origins of replication Replication bubble: Overview Biology 6B 07 Molecular Genetics Brian McCauley Spring 2010 Replication fork Leading Strand Synthesis Leading & Lagging Lagging Strand Synthesis Topoisomerase undoes supercoiling. DNA Replication: Details Helicase unwinds the double helix. DNA Replication: Details Biology 6B 07 Molecular Genetics Brian McCauley Spring 2010 Single-strand binding proteins hold the strands apart. DNA Replication: Details DNA Replication: Details 1 2 3 4 Primase makes RNA primers DNA Replication: Details 1 2 3 4 DNA pol III adds nucleotides to 3’ ends DNA Polymerases make DNA DNA Replication: DNA Polymerase DNA Replication: Details 1 2 3 4 DNA pol I replaces RNA primer with DNA DNA Replication: Details 1 2 3 4 Ligase joins Okazaki fragments together Biology 6B 07 Molecular Genetics Brian McCauley Spring 2010 Replication complex Repairing damaged DNA thymine dimer The end-replication problem Repetitive, noncoding DNA on chromosome ends. Protect against end-replication problem. No telomeres? No cell proliferation. Telomeres Telomerase has its own RNA template Telomeres form loops on chromosome ends Biology 6B 07 Molecular Genetics Brian McCauley Spring 2010 Ch. 17: From Gene to Protein Transcription: making RNA Translation: making polypeptides Control of gene expression What is a gene? Genome sizes How similar are chimpanzees and humans? Chimps and humans Common ancestor 6 million years ago. 29 % of proteins are identical. Average protein differs by 2 amino acids. 2.7% of genome has been inserted or deleted. The difference is in the expression 2-D protein electrophoresis Brain proteins Biology 6B 07 Molecular Genetics Brian McCauley Spring 2010 How similar are asian & caucasian people?...
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This note was uploaded on 09/02/2011 for the course BIOL 6a taught by Professor Staff during the Fall '10 term at DeAnza College.

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07MolecularGenetics11Sp - What does DNA do? DNA, Genes,...

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