10.5Pericentrin

10.5Pericentrin - Biology 6B 10.5 Mendelian extra:...

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1 How to find a gene? mapping Genetic markers Microcephalic osteodysplastic primordial dwarfism (MOPD): 8 years; 84 cm 8 years; 85 cm 12 years; 95 cm Biology 6B 10.5 Mendelian extra: Pericentrin Gene Mapping Brian McCauley Spring 2011
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2 Microcephalic osteodysplastic primordial dwarfism (MOPD II): Rare recessive disorder Different from other types of dwarfism Extremely small stature Not premature aging Pedigrees for MOPD Consanguineous lineages Homozygosity mapping Markers: polymorphic noncoding DNA sequences Identify chromosomal regions correlated with MOPD Biology 6B 10.5 Mendelian extra: Pericentrin Gene Mapping Brian McCauley Spring 2011
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3 Finding the MOPD gene Linkage mapping: find chromosomal region correlated with MOPD. Human genome sequence: pericentrin gene located in that region. Pericentrin: centrosome protein;
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10.5Pericentrin - Biology 6B 10.5 Mendelian extra:...

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