10.6Viruses11Sp

10.6Viruses11Sp - blocks viral DNA polymerase but not...

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1 Viruses aren’t cells. Viruses have genomes but need a host cell to reproduce. λ Bacteriophage Life Cycle T4 Bacteriophage Life Cycle plaques Retrovirus (HIV) Life Cycle RNA genome reverse transcribed to make DNA copy. DNA may be inserted into chromosome. Virions have Biology 6B 10.6 Viruses Brian McCauley Spring 2011
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2 HIV Antiviral Drugs Reverse transcriptase inhibitors. Protease inhibitors. Fusion inhibitors. Integrase inhibitors. HIV Life Cycle Antiviral drugs only attack replicating virus. Viral DNA may hide in heterochromatin. “Purge drugs” unwind chromatin, starting viral replication. .. ... and letting drugs kill virus. Herpes virus infection DNA virus with capsid DNA gets transcribed in nucleus. Infection may be latent for long periods. Acyclovir, a nucleoside analog Used for treatment of herpes virus infection. Similar to a nucleotide;
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Unformatted text preview: blocks viral DNA polymerase but not cellular DNA polymerase. Some cancers are caused by viruses hpv: human papillomavirus Virus proteins deregulate cell cycle Biology 6B 10.6 Viruses Brian McCauley Spring 2011 3 RNA Virus Life Cycle Membrane envelope 8 RNA segments, 10 proteins Easily recombines Influenza Virus Structure Hemagglutinin membrane glycoprotein binds to host cells helps viral membranes fuse with host membranes Neuraminidase helps virions get released from host cells H1N1 Influenza Virus Hemagluttinin amino acid sequences J. Cohen Science 324, 870 -871 (2009) B. Olsen et al., 312, 384 -388 (2006) Influenza A Phylogeny 2009 Swine flu virus J. Cohen 324, 1127 (2009) Biology 6B 10.6 Viruses Brian McCauley Spring 2011...
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10.6Viruses11Sp - blocks viral DNA polymerase but not...

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