osteoarthritis risk factors

osteoarthritis risk factors - NIH C ONFERENCE...

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NIH CONFERENCE Osteoarthritis: New Insights Part 1: The Disease and Its Risk Factors Conference Chair. David T. Felson, MD, MPH; Conference Organizer: Reva C. Lawrence, MPH; Discussants: Paul A. Dieppe, MD; Rosemarie Hirsch. MD, MPH; Charles C. Helmick, MD; Joanne M. Jordan, MD, MPH; Raynard S. Kington, MD, PhD; Nancy E. Lane, MD; Michael C. Nevitt, PhD; Yuqing Zhang, DSc; MaryFran Sowers, PhD; Timothy McAlindon, MD, MPH; Tim D. Spector, MD, MSc; A. Robin Poole, PhD, DSc; Susan Z. Yanovski, MD; Gerard Ateshian, PhD; Leena Sharma, MD; Joseph A. Buckwalter, MD; and Kenneth D. Brandt, MD; and James F. Fries, MD Osteoarthritis is the most common form of arthritis, affecting millions of people in the United States. It is a complex disease whose etiology bridges biomechanics and biochemistty. Evidence is growing for the role of systemic factors (such as genetics, dietary intake, estrogen use, and bone density) and of local bio- mechanical factors (such as muscle weakness, obesity, and joint laxity). These risk factors are particularly important in weight- bearing joints, and modifying them may present opportunities for prevention of osteoarthritjs-related pain and disability. Major ad- vances in management to reduce pain and disability are yielding a panoply of available treatments ranging from nutriceuticals to chondrocyte transplantation, new oral anti-inflammatory medica- tions, and health education. This article is part 1 of a two-part summary of a National Institutes of Health conference. The con- ference brought together experts on osteoarthritis from diverse backgrounds and provided a multidisciplinaiy and comprehensive summary of recent advances in the prevention of osteoarthritis onset, progression, and disability, Part 1 focuses on a new under- standing of what osteoarthritis is and on risk factors that predis- pose to disease occurrence. It concludes with a discussion of the impact of osteoarthritis on disability. Ann Intern Med. 2OOO;133:635-646, For author affiliations and current addresses, see end of text. OSTEOARTHRITIS: THE DISEASE AND ITS PREVALENCE AND IMPACT Dr. David T. Felson (Boston University School of Medicine, Boston, Massachusetts), Ms. Reva C. Lawrence {National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health [NIH], Be- thesda, Maryland), Dr. Paul A. Dieppe (University of Bris- tol, Bristol, United Kingdom), Dr. Rosemarie Hirsch (Na- tional Center for Health Statistics, Centers for Disea.çe Control and Prevention [CDC], Hyattsville, Maryland), and Dr. Charles G. Helmick (National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, Georgia); For many years, osteoarthritis has been seen as a dull, commonplace disorder with few treatment options. That view is rapidly changing. Recent epidemiologic, clin- ical, and treatment studies have combined to produce a picture of a surprisingly complex disease whose pathophys- ioiogy bridges biomechanics and biochemistry and whose treatments range from surgery to nutriceuticals to patient education interventions. These understandings have al- ready led to a shift in the approach to treatment.
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This note was uploaded on 09/05/2011 for the course COMM 101 taught by Professor Staff during the Spring '08 term at Boise State.

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osteoarthritis risk factors - NIH C ONFERENCE...

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