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Chapter6_Spring2011

Chapter6_Spring2011 - CNS Depressants Sedative-Hypnotics...

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CNS Depressants: Sedative-Hypnotics Chapter 6
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Introduction to CNS Depressants Why are CNS depressants problematic? - Usually prescribed under physician direction - Can cause very alarming and dangerous behavior if not closely monitored Most problems associated with these drugs due to inadequate professional supervision
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Introduction to CNS Depressants Why are CNS depressants problematic? - Seemingly unrelated drug groups can cause CNS depression - Combination use can cause dangerous drug interactions - Can cause disruptive personality changes
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The History of CNS Depressants Attempts to find CNS depressants other than alcohol began in the 1800s. Bromides were introduced to treat nervousness and anxiety in the 1800s. - Very popular but toxic. In the early 1900s, bromides were replaced by barbiturates. - Initially heralded as safe and effective. - Problems with tolerance, dependence, and safety became apparent.
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The History of CNS Depressants In the 1950s the first benzodiazepines were marketed as substitutes for barbiturates. - Relatively safe when used for short periods - Long-term use can cause dependence and withdrawal problems
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The History of CNS Depressants Benzodiazepines were routinely prescribed for stress, anxiety, or apprehension. - In 1973 100 million prescriptions were written for benzodiazepines. - Twice as many women as men taking them.
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