02c-COGS17-Neurodevelopment

02c-COGS17-Neurodevelopment - Neurodevelopment...

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eurodevelopment Neurodevelopment MARY ET BOYLE, PH.D. DEPARTMENT OF COGNITIVE SCIENCE CSD UCSD
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Brain Development roliferation Proliferation Differentiation igration Migration Axon and dendrite development ynaptogenesis Synaptogenesis Synapse Pruning poptosis rogrammed cell death Apoptosis – programmed cell death
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Embryonic Brain Development Nervous system develops from ectoderm
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Properties of Stem Cells Self-renewal Maintain an undifferentiated state after numerous cycles of cell division. otency Potency The capacity to differentiate into specialized cell types. Totipotent – differentiate into embryonic cell types l i t t diff ti t i t l ll ll Pluripotent–can differentiate into nearly all cells Cells are derived from any of the three germ layers. Multipotent – can differentiate into a number of cells, but only ose of a closely related family of cells those of a closely related family of cells. Oligopotent – can differentiate into only a few cells Unipotent – can produce their own cell type – maintain the roperty of self newal property of self-renewal.
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Unipotent Totipotent Multipotent luripotent Pluripotent Oligopotent
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Stem Cells Neural plate cells Appear the have unlimited capacity for self-renewal Totipotent – can develop into different mature cell types As the neural tube develops, specificity increases: Multipotent – lial em cells Glial stem cells Neural stem cells
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ingle cell
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This note was uploaded on 09/07/2011 for the course COGS 17 taught by Professor Pineda during the Spring '06 term at UCSD.

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02c-COGS17-Neurodevelopment - Neurodevelopment...

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