02c-platsticity-slides

02c-platsticity-slides - subsequent axons of the same nerve...

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10/14/2009 1 Roger Sperry’s Classic Experiment (1940’s) Frog behavior: Dangle a lure frog will grab it with its tongue. Roger Sperry’s Classic Experiment (1940’s) Frog visual system
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10/14/2009 2 Minds and Brains, Winter 2005 January 28, 2005
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10/14/2009 3
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10/14/2009 4
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10/14/2009 5 How do neurons know were to go??? Roger Sperry (1963) Chemoaffinity Hypothesis: Postsynaptic surface has chemical tags that direct the neuron to its proper location In vitro experiments retina tectum
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10/14/2009 6 It does not account for... targets transplanted to novel positions sometimes innervate the incorrect target. Some axons follow the same circuitous route to their target in every member of a species, rather than growing directly to the target. Not enough genes to account for a different chemical tag for every neuron to reach its proper location. Blue Print Hypothesis... The undeveloped nervous system contains specific chemical or Pioneer axons mechanical trails that growing axons follow to their destinations.
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Unformatted text preview: subsequent axons of the same nerve never made it to their target. 10/14/2009 7 Chick Spinal Cord: Muscle Innervation ??? Topographic Gradient Hypothesis retina tectum 10/14/2009 8 retina Optic tectum If one lesions 1/2 the retina & nerve. .. retina Optic tectum The remaining ones systematically project over the entire tectum. 10/14/2009 9 If one lesions 1/2 the tectum & nerve cut. .. retina Optic tectum The retinal ganglion cells projected systematically over the remaining half tectum. Diffuse pattern of synaptic contact Early stages of development 10/14/2009 10 Focused pattern of synaptic contact After synapse rearrangement has occurred 10/14/2009 11 What happens when. .. Mechanisms of neural reorganization. .. 10/14/2009 12 Minds and Brains, Winter 2005 February 2 Minds and Brains, Winter 2005 February 2 10/14/2009 13 Minds and Brains, Winter 2005 February 2 The case of Tom and Philip. .. 10/14/2009 14...
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