04-COGS17-Psychopharmacology-Part2a

04-COGS17-Psychopharmacology-Part2a - 10/23/2009...

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10/23/2009 1 Acetylcholine Mary ET Boyle, Ph.D. Cognitive Science •Act on neurons in their own immediate vicinity, generally at the synapse Neurotransmitters Neurohormones •Are chemical messengers that act on neurons somewhat farther away by diffusing away from their site of release. •Are capable of producing effects at target cells quite distant from their site of release. Nh ft tl i th bl d l Neuromodulators Neurohormones often travel in the blood supply to reach their final targets.
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10/23/2009 2 Sir Henry Dale 1875 1968 Dale’s Principle or (Dale’s Law) The same chemical transmitter is released from all the synaptic terminals of a neuron. Neurotransmitter Characteristics • Synthesized within the neuron. •Must have an effect. • Duplicate it experimentally. • A mechanism that ends the interaction.
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10/23/2009 3 Amino acids GABA Glutamate 6 others Catecholamines: Dopamine Small Molecule Transmitters Amines (Monoamines) Norepinephrine Epinephrine Indolamines: Serotonin Melatonin Acetylcholine (ACh) ATP and its byproducts Nervous System Central Nervous System Peripheral Nervous System Skeletal (somatic) voluntary muscle control Autonomic smooth muscles d ld Brain Spinal Cord and glands
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10/23/2009 4 Autonomic Nervous System Sympathetic Nervous System Parasympathetic Nervous System Fight or Flight Rest and Digest Acetylcholine (ACh) C 7 H 16 NO 2
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10/23/2009 5 Otto Loewi 1921 Demonstrated that synaptic signaling was chemical Acetylcholine Cholinergic Neurons Neurons that use Acetylcholine as their neurotransmitter.
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10/23/2009 6 acetyl-CoA choline ChAT CoA ACh Coenzyme A Coenzyme A Acetate ion Choline acetyltransferase Choline
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This note was uploaded on 09/07/2011 for the course COGS 17 taught by Professor Pineda during the Spring '06 term at UCSD.

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04-COGS17-Psychopharmacology-Part2a - 10/23/2009...

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