Elaine's Lecture Placebo and PNI

Elaine's Lecture Placebo and PNI - Focusing on Placebo...

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Focusing on Placebo Effect and Psychoneuronimmunology 1
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Mind over Matter Walking on coals Positive Thinking Placebo Effect Convincing yourself of illness Headache, cold, H1N1, food poisoning Getting “buzzed” from a non-alcoholic drink Hives from Stress Hysterical pregnancy (Symptoms of pregnancy but no fetus) Somatoform Disorders 2
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Is this real or is it all in your head?? Yes and Yes An increasing number of studies have found that we can imagine and convince ourselves of various realities (in our head) But… Sometimes they are also being carried out on the anatomical, physiological, and molecular, level (it is real) 3
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Some communication methods we already know Classically conditioning the immune system? Psychoneuroimmunology Definition Nervous and Immune system interface: the BBB Top Down vs. Bottom Up Placebo Effect Definition Examples of use Placebo and Depression Possible structures involved 4
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Somatic Pathways Muscle Stimulation Output Sensory Information Input Autonomic Pathways (rest and digest/fight or flight) Sympathetic and Parasympathetic Two Patterns Direct innervation via Neuron (ACh Heart) Hormone released into the bloodstream (from hypothalamus/pituitary) Pharmacology of Drugs Injection, ingestion, inhalation, etc We take cocaine, it passes the BBB, and our DA reuptake is blocked. All of these systems have a sender and receiver who can understand the messages being exchanged Presynaptic neuron can synthesize ACh Postsynaptic neuron has an ACh receptor Old idea: the immune system and nervous system do not posses this ability 5
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1975 Psychosomatic Medicine, Robert Ader
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This note was uploaded on 09/07/2011 for the course COGS 17 taught by Professor Pineda during the Spring '06 term at UCSD.

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Elaine's Lecture Placebo and PNI - Focusing on Placebo...

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