The%20vascular%20Disease%20Lecture%20Aug%2009_student%20pt%20A_pptx

The%20vascular%20Disease%20Lecture%20Aug%2009_student%20pt%20A_pptx

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By Dr Brett Lillie - 2009 By Dr Brett Lillie August 2008
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Stroke is leading cause of diability in adults Incidence doubles ea decade past 55yrs (1/2 occur b/w 70 – 75yrs) By Dr Brett Lillie - 2009
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25% of adult pop has arterial 1. Hypertension = systolic BP above 140mg Hg (high normal BP is 130-139mg HG) Predisposes to ischemia by agg arteriosclerosis & accelerating Heart dis. Macrovascular disease is the leading cause of death among people with 2. Diabetes Mellitus By Dr Brett Lillie - 2009
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Smoking is the leading cause of preventable death Increase risk of stroke 2 – 3 x’s By Dr Brett Lillie - 2009
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By Dr Brett Lillie - 2009
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Impairment of energy metabolism Loss of aerobic glycolysis Increase intracellular Na + Ca ions Increase in Lactate levels Free radical production Cell swelling Increase in activity of lipases + proteases By Dr Brett Lillie - 2009
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12-15 secs suppression of electrical activity 2-4mins inhibition of synaptic excitability 4-6 mins inhibition of electrical excitability 6 hrs Microscopic changes of an infarct By Dr Brett Lillie - 2009
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Pathology depends on 1. mechanism 2. size of obstructed a. 3. availability of collateral b. flow By Dr Brett Lillie - 2009
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Caused by several pathological processes involving the blood vessels of the brain. Either 1. Intrinsic to the b. vessel atherosclerosis, lipophyalinosis, inflammation, arterial dissection, developmental malformation, aneurysmal dilation or venous thrombosis. 2. Originate from another area embolus from heart or extracranial circulation. 3. Decreased perfusion pressure or blood viscosity By Dr Brett Lillie - 2009
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Stroke Def: Acute neurological injury due to one of these pathological processes becoming either a brain infarction or hemorrhage. - 80% is ischemic cerebral infarction - 20% is brain hemorrhage Treatment requires precise diagnosis Characterised by history and physical examination especially a clear account of the course of events before the stroke.
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This note was uploaded on 07/15/2011 for the course ECO 2023 taught by Professor Mr.raza during the Summer '10 term at FAU.

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The%20vascular%20Disease%20Lecture%20Aug%2009_student%20pt%20A_pptx

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