Copy of HMB265 Final 2002 003 - fl WJMOF W NO x 3 A...

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Unformatted text preview: fl? WJMOF W_ NO x 3. A minisatellite marker band presentr in a mother k——#——_fi . a) must be present in all children _ bfcannot be present in any of her children We) vyill be rare in her children Idliwill be in 1/4 of her children on average e) will be present in U2 of her children on average 9. During sequencing of the human genome by the Human Genome Project, fingerprint clone contigs of BACs were made using a) Southern blotting ...r-u- ~-'-'“" STS markers M Striction digest patterns I fir)” FISH e) linkage analysis 10. A woman has cystic fibrosis. She is the only person in her family with this disease. If her unaffected brother marries a woman with no family history of cystic fibrosis, what is the probability that their child will be a carrier of the CF gene? Q??? b) 1/4 .2. PCJ'JTQF BBL.— ,L 9 3 :1 ) c) 1/6 _ d) 1/12 a? (WI *9"— C) 1/24 1 1. Which of these statements best describes the reason why rat—(iiatiomhflmm can be used to create high~resolution chromosome maps of human chromosomes? a) chromosomes can be broken by exposure to ultraviolet rays 1}) the distance between markers and genes can be estimated by statistical analysis of retention frequencies c) hamster cells preferentially retain single fragments of human chromosomes d) the distance between markers and genes can be estimated using meiotic recombination frequencies e) genes on separate chromosomes are co-retainecl in hybrid clones at high frequencies 12. Chiasma, with a vestige of the synaptoriemal complex, is observed during which stage of prophase I of meiosis? a) leptotene b) zygotene c) pachytene d) diplotene e) diakinesis April 30, 2002 Page 4 of l4 ...
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