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Unformatted text preview: o Methylation of DNA silences genes o DNA methyltransferases o %’-CG-#’ or %’CNG-3” sequences o In higher eukaryotres 10 to 30% of cytosines o Maintenance and de novo DNA methlytransferases. Maintenance- recognizes hemi mehtylated strand and add methyl group to other C on the strand De novo- a additional methyl group is added to a strand that didn’t have it before. o De novo mehtlyation is needed for normal mammalian embryo development Dnmtl- maintance DNA mathylase Dwmt3a and dnmt3b de novo methylases (KO causes embryo death)...
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