10.6 - Permanent DNase1 hypersensitiviy marked by binding...

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Insulators o Maintains the independence of a functional domain o Prevents cross-talk between domains o How they work is not known but binding proteins are necessary e.g Su(HW), which also bind to the nuclear matrix. Locus control region (LCR) o Maintains chromatin in an open state. Unlike insulators o Like insulators LCR overcome positional effects o Unlike insulators, LCR stimulates expression of all genes.
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Unformatted text preview: Permanent DNase1 hypersensitiviy marked by binding proteins o Transient DNase1 sites related to expression (only when gene is being expressed) A= no expression after rearrangement B= expression 3 kinds of modifications o Basic amino acid modification. Lysine or serine both become modified Methylated or acetylated. Serine is phosphorilated...
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10.6 - Permanent DNase1 hypersensitiviy marked by binding...

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