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Unformatted text preview: 4 extracellular segments, 4 cytosolic regions B-adrenergic for epinephrine Alpha subunit transduces the signal to effector ( alpha s stimulates , alpha i inhibits ) FRET: detects G protein activation bc YFP on gamma is activated only when its near the tag on alpha. C3 loop is where G Proteins bind- determined by chimeric receptors Response specificity is determined by type of ligand, GPCR, G protein, & effector Beta gamma subunit associates with K+ channels = open, heart muscle regulation...
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- Spring '11