Unformatted text preview: • 4 extracellular segments, 4 cytosolic regions • B-adrenergic for epinephrine • Alpha subunit transduces the signal to effector ( alpha s stimulates , alpha i inhibits ) • FRET: detects G protein activation bc YFP on gamma is activated only when its near the tag on alpha. • C3 loop is where G Proteins bind- determined by chimeric receptors • Response specificity is determined by type of ligand, GPCR, G protein, & effector • Beta gamma subunit associates with K+ channels = open, heart muscle regulation...
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- Spring '11
- b. Adenylyl cyclase, binds regulatory subunits, releases catalytic subunits, control smooth muscle