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ST 5 - 2 neural stimulation of muscle ups Ca epinephrine...

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Chapter 15.6-.8, 16.3-.5, 24.5 I. cAMP – cell specific responses 1. glycogen metabolism in liver and muscle cells: increased cAMP PKA inhibits glycogen synthesis , promotes glycogen degradation, PP is inhibited from dephosphorylating the cascade or inactive glycogen synthase 2. decreased cAMP deactivated PKA active PP II. PKA – scaffolded by proteins to membrane 1. AKAP – anchoring protein 2. PDE – phosphorylated by PKA to downregulate cAMP III. Ca2+ regulates cell responses 1. interaction of signaling pathways specify cell responses
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Unformatted text preview: 2. neural stimulation of muscle: ups Ca, epinephrine ups cAMP = glycogen phosphorylase kinase 3. hormonal stim of liver receptors: ups cAMP, DAG, and IP3. IP3 ups Ca2+, glycogen degradation. DAG activates PKC. PKA and PKC block glycogen synthesis IV. Receptor Tyrosine Kinases 1. ligand binding homo dimerization (loop segment interactions) 2. dimerization activates intrinsic kinases= cross phosphorylation of lips, phosphorylates additional Ys on cytosolic side...
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