Cell Cycle 1 - DNA is duplicated in S phase. Reassembled in...

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Go, G1 G1 pre-replication complexes S phase ORI Cohesions G2 M phase Interphase Prophase prometa meta anaphase cyclin CDKs Catalytic subunit – quiescent state, no DNA replication/growth. 1 chromosome/DNA molc, enters G1 from growth factors, metabolically active -Stage of growth and high metabolic activity At ORI, includes replication initation factors Cdc6 and Cdt1. phosphorylation by S-phase cylcin CDKs releases factors and allows replication to proceed. Factors remain phosphorylated, preventing them from reinitiating replication DNA replicates, each chromosome has two sister chromatids connected at centromere by proteins Many sites, both directions, ORI complex reforms after
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Unformatted text preview: DNA is duplicated in S phase. Reassembled in hypo? phosphorylated form (inactive ) Connect sister chromatids around centromere All genomic DNA has been duplicated Separates two copies of genome into separate cells. Only starts after checkpoints. Consistes of Pro, Meta and Telophase Chromosome duplications and cohesion (G1, G2, S) Asters and mt dev. Nuclear envelope breakdown, chromosomes caught by spindles Chromosomes aligned at middle At poles Regulatory compnenet of CDKs, Cyclin dependent kinases regulate cell cycle by protein phosphorylation, heterodimeric, contains catalytic and regulatory components. Do not fluctuate, inactive when not associated w kinase...
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This note was uploaded on 09/08/2011 for the course CELL BIO & 01:146:473 taught by Professor Brewer during the Spring '11 term at Rutgers.

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