Unformatted text preview: A transition (chromosome separation), and A to T transition. An E3 ubiquitin ligase. Controlled by two different specificity factors: Cdc20 or Cdh1 (activated when one of these binds). High level throughout cell cycle. A ubiquitin ligase that regulates transition for G1 to S, is a protein complex. High level throughout cell cycle Is irreversible, so the cells has to move forward toward division Revealed cyclin protein and that its levels changed during the cell cycle Set up cells for S phase Turn on ORIs. In yeast, degradation of Sphase inhibitor triggers DNA replication. Accumulate during G1, but are inhibited Sphase cyclin inhibitor that becomes hyperphosphorylated as G1 cyclins build up in cell, and undergoes ubiquitination by SCF ligase...
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- Spring '11
- Cell Cycle, Ubiquitin ligase, E3 ubiquitin ligase, SCF ligase