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Cell Cycle 3 - Driven by APC/C ubiquitin ligase Activate...

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Mitotic cyclin CDKs Nuclear lamins phosphorylation Nuclear pore proteins phosphorylated Inner nuclear membrance proteins phophorylated Chromatin protein phosphorylation kinetochores M -> A transition Cdc20 Kleisin Cdc14 phosphatase Reversal of MPF phosphorylation G1 restriction point E2 transcription factors Activate early steps of mitosis. Expressed in S and G2 as inactive forms. Completion of DNA rep triggers activation by phosphatases. Connected in network as dimers. Phosphorylated to disassemble the nuclear membrane Dissociated into soluble membrane sub complexes Block binding with nuclear lamina and chromatin Triggers chromatin condensation and blocks binding w nuclear envelope Captured bipolarly by spindle MTs to move chromosomes to Metaphase plate
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Unformatted text preview: Driven by APC/C ubiquitin ligase. Activate separase, aprotease for cohesions by ubiquitinating its inhibitor, securin b degraded by proteasome. Activated by signaling that detects when kinetochores are captured. Binds to apc/c and activates its activity Subunit of cohesions that is cleaved by separase Activation after chromosome separation, desphosphorylates proteins phosphorylated by MPF and Cdh1 (thus activating it to bind APC/C ->ubiqitinates M phase cyclins Chromosome condensation, nuclear pore and membrane reassembly Prevents movt into S until environment is right. Inactivated by Rb until growth factors stimulate CDKs in mid G1 to hyperphophorylate Rb. Then stimulates synthesis of itself and more CDKs....
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