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Unformatted text preview: Driven by APC/C ubiquitin ligase. Activate separase, aprotease for cohesions by ubiquitinating its inhibitor, securin b degraded by proteasome. Activated by signaling that detects when kinetochores are captured. Binds to apc/c and activates its activity Subunit of cohesions that is cleaved by separase Activation after chromosome separation, desphosphorylates proteins phosphorylated by MPF and Cdh1 (thus activating it to bind APC/C ->ubiqitinates M phase cyclins Chromosome condensation, nuclear pore and membrane reassembly Prevents movt into S until environment is right. Inactivated by Rb until growth factors stimulate CDKs in mid G1 to hyperphophorylate Rb. Then stimulates synthesis of itself and more CDKs....
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This note was uploaded on 09/08/2011 for the course CELL BIO & 01:146:473 taught by Professor Brewer during the Spring '11 term at Rutgers.
- Spring '11