Cell Cycle 4 - Binds directly to unattached kinetochores...

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Rb Spindle Assembly Checkpoint Mad 1 Mad 2 Intra-S phase checkpoint DNA damage checkpoints Part of G1 restriction point. Suppresses E2 transcription by binding to histone deactylases and methylases. M and S phase cyclins maintain its hyperphosphorylation Mad1/2 detects unattached kinetochores. Checkpoint inactivated when MTs attach and displace it, and allow p31 to free Cdc20 to bind APC/C
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Unformatted text preview: Binds directly to unattached kinetochores Binds to Cdc20 to inhibit it, or more Mad 2 to facilitate binding more Cdc20 ATR detects replication forks and blocks entry into mitosis by phosphorylation of Cdc25 which activates MPF Activated by ATM and ATR at different points of cell cycle. Act through p53 tumor suppressor b many outcomes...
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This note was uploaded on 09/08/2011 for the course CELL BIO & 01:146:473 taught by Professor Brewer during the Spring '11 term at Rutgers.

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