Unformatted text preview: Binds directly to unattached kinetochores Binds to Cdc20 to inhibit it, or more Mad 2 to facilitate binding more Cdc20 ATR detects replication forks and blocks entry into mitosis by phosphorylation of Cdc25 which activates MPF Activated by ATM and ATR at different points of cell cycle. Act through p53 tumor suppressor b many outcomes...
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- Spring '11
- Cell Cycle, DNA Damage, G1 restriction point, detects unattached kinetochores, Intra-S phase checkpoint